Copper(II) and Cobalt(II) Complexes Based on Methyl Trifluorosalicylate and Bipyridine-Type Ligands: Synthesis and Their Antimicrobial Activity

24 Pages Posted: 10 Aug 2020

See all articles by Evgeny V. Shchegolkov

Evgeny V. Shchegolkov

Russian Academy of Sciences (RAS) - Ural Branch

Irina V. Shchur

Russian Academy of Sciences (RAS) - Ural Branch

Yanina V. Burgart

Russian Academy of Sciences (RAS) - Ural Branch

Pavel A. Slepukhin

Russian Academy of Sciences (RAS) - Ural Branch

Natalia P. Evstigneeva

affiliation not provided to SSRN

Natalia Gerasimova

The Bohdan Khmelnytsky National University of Cherkasy - Scientific-Research Institute of Pedagogical Education, Social Work and Arts

Natalia V. Zilberberg

affiliation not provided to SSRN

Nikolai V. Kungurov

affiliation not provided to SSRN

Victor I. Saloutin

Russian Academy of Sciences (RAS) - Ural Branch

Oleg N. Chupakhin

Russian Academy of Sciences (RAS) - Ural Branch

Abstract

The synthesis of bis(salicylato)Cu(II) and Co(II) chelates based on methyl trifluorosalicylate and the corresponding M(OAc) 2 in the presence of alkali is reported. The following reaction with 2,2’-bipyridine and 1,10 phenanthroline in refluxing methanol affords heteroligand complexes containing methyl trifluorosalicylate and azaheterocyclic ligands in the ratio 2:1. However, the refluxing of Co(II) chelates in ethanol resulted in transesterification of methyl ester group to form heteroligand complexes of ethyl trifluorosalicylate while Cu(II) chelates underwent hydrolysis of ester group to obtain heteroligand complexes of trifluorosalicylic acid. The structures of obtained metal complexes were confirmed by X-Ray diffraction experiment, IR spectroscopy and elemental analysis. The antimycotic and antibacterial activities of synthesized metal complexes were investigated. The heteroligand metal complexes were found to exhibit moderate anti-Candida albicans activity. Among new series of complexes, the most activity showed the mixed metal complexes of trifluorosalicylates and 1,10-phenanthroline revealing a wide range of action in relation to pathogenic fungi and bacteria.

Keywords: polyfluorinated salicylic acids esters, heteroligand metal complexes, bipyridine-like ligands, transesterification and hydrolysis, antimycotic and antibacterial activity

Suggested Citation

Shchegolkov, Evgeny V. and Shchur, Irina V. and Burgart, Yanina V. and Slepukhin, Pavel A. and Evstigneeva, Natalia P. and Gerasimova, Natalia and Zilberberg, Natalia V. and Kungurov, Nikolai V. and Saloutin, Victor I. and Chupakhin, Oleg N., Copper(II) and Cobalt(II) Complexes Based on Methyl Trifluorosalicylate and Bipyridine-Type Ligands: Synthesis and Their Antimicrobial Activity. Available at SSRN: https://ssrn.com/abstract=3670315

Evgeny V. Shchegolkov

Russian Academy of Sciences (RAS) - Ural Branch ( email )

Kovalevskoy, 16
Ekaterinburg
Russia

Irina V. Shchur

Russian Academy of Sciences (RAS) - Ural Branch ( email )

Kovalevskoy, 16
Ekaterinburg
Russia

Yanina V. Burgart

Russian Academy of Sciences (RAS) - Ural Branch ( email )

Kovalevskoy, 16
Ekaterinburg
Russia

Pavel A. Slepukhin

Russian Academy of Sciences (RAS) - Ural Branch ( email )

Kovalevskoy, 16
Ekaterinburg
Russia

Natalia P. Evstigneeva

affiliation not provided to SSRN

No Address Available

Natalia Gerasimova

The Bohdan Khmelnytsky National University of Cherkasy - Scientific-Research Institute of Pedagogical Education, Social Work and Arts ( email )

Ukraine

Natalia V. Zilberberg

affiliation not provided to SSRN

No Address Available

Nikolai V. Kungurov

affiliation not provided to SSRN

No Address Available

Victor I. Saloutin (Contact Author)

Russian Academy of Sciences (RAS) - Ural Branch ( email )

Kovalevskoy, 16
Ekaterinburg
Russia

Oleg N. Chupakhin

Russian Academy of Sciences (RAS) - Ural Branch ( email )

Kovalevskoy, 16
Ekaterinburg
Russia

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