Case Histories of Significant Medical Advances: Cephalosporins

18 Pages Posted: 24 Aug 2020 Last revised: 9 Jun 2021

See all articles by Amar Bhide

Amar Bhide

Tufts University - The Fletcher School of Law and Diplomacy

Srikant Datar

Harvard University - Accounting & Control Unit

Katherine Stebbins

Harvard University - Business School (HBS)

Date Written: May 15, 2021

Abstract

Our case history describes the development of three generations of cephalosporins – antibiotics that have significantly reduced hospital infections. After providing an overview of antibiotic development and its challenges we describe how: 1) Early (pre-cephalosporin) antibiotics were developed in the first half of the 20th century, 2) Drug companies developed first-generation cephalosporins in the 1960s using foundational discoveries made by researchers in Italy and the UK in the 1940s and 1950s, and 3) Continued modifications of cephalosporin molecules resulted in second and third generations of the drugs in the 1970s and 1980s.

Suggested Citation

Bhide, Amar and Datar, Srikant and Stebbins, Katherine, Case Histories of Significant Medical Advances: Cephalosporins (May 15, 2021). Harvard Business School General Management Unit Working Paper No. 20-133, Harvard Business School Accounting & Management Unit Working Paper No. 20-133, Available at SSRN: https://ssrn.com/abstract=3679640 or http://dx.doi.org/10.2139/ssrn.3679640

Amar Bhide

Tufts University - The Fletcher School of Law and Diplomacy ( email )

Cabot 505
160 Packard Avenue
Medford, MA 02155
United States
617-229-5050 (Phone)

HOME PAGE: http://www.bhide.net

Srikant Datar (Contact Author)

Harvard University - Accounting & Control Unit ( email )

Soldiers Field
Boston, MA 02163
United States
617-495-6543 (Phone)
617-496-7363 (Fax)

Katherine Stebbins

Harvard University - Business School (HBS) ( email )

Soldiers Field Road
Morgan 270C
Boston, MA 02163
United States

Do you have a job opening that you would like to promote on SSRN?

Paper statistics

Downloads
12
Abstract Views
341
PlumX Metrics