Genomic Evidence for a Case of Reinfection with SARS-CoV-2

18 Pages Posted: 31 Aug 2020

See all articles by Richard Tillett

Richard Tillett

Nevada Institute for Personalized Medicine; Nevada Center for Bioinformatics

Joel Sevinsky

THEIAGEN CONSULTING

Paul Hartley

University of Nevada, Reno

Heather Kerwin

WASHOE COUNTY HEALTH DISTRICT

Natalie Crawford

RENOWN HEALTH

Andrew Gorzalski

University of Nevada, Reno - NEVADA STATE PUBLIC HEALTH LABORATORY

Christopher Laverdure

University of Nevada, Reno - NEVADA STATE PUBLIC HEALTH LABORATORY

Subhash Verma

University of Nevada, Reno - School of Medicine

Cyprian Rossetto

University of Nevada, Reno - School of Medicine

David Jackson

WASHOE COUNTY SHERIFF'S FORENSIC SCIENCE DIVISION

Megan Farrell

WASHOE COUNTY SHERIFF'S FORENSIC SCIENCE DIVISION

Stephanie Van Hooser

University of Nevada, Reno - NEVADA STATE PUBLIC HEALTH LABORATORY

Mark Pandori

University of Nevada, Reno - Nevada State Public Health Laboratory

Date Written: August 25, 2020

Abstract

The degree of protective immunity conferred by infection with SARS-CoV-2 is currently unknown. As such, the possibility of reinfection with this virus is not well understood. Herein, we describe the data from an investigation of two instances of SARS-CoV-2 infection in the same individual. Through nucleic acid sequence analysis, the viruses associated with each instance of infection were found to possess a degree of genetic discordance that cannot be explained reasonably through short-term in vivo evolution. We conclude that it is possible for humans to become infected multiple times by SARS-CoV-2, but the generalizability of this finding is not known.

Note: Funding: Grants from the National Institute of General MEdical Sciences (GM103440 and GM104944) from the National Institutes of Health.
br> Declaration of Interest: None to declare

Keywords: SARS-CoV-2, reinfection, genetic

Suggested Citation

Tillett, Richard and Sevinsky, Joel and Hartley, Paul and Kerwin, Heather and Crawford, Natalie and Gorzalski, Andrew and Laverdure, Christopher and Verma, Subhash and Rossetto, Cyprian and Jackson, David and Farrell, Megan and Van Hooser, Stephanie and Pandori, Mark, Genomic Evidence for a Case of Reinfection with SARS-CoV-2 (August 25, 2020). Available at SSRN: https://ssrn.com/abstract=3680955 or http://dx.doi.org/10.2139/ssrn.3680955

Richard Tillett

Nevada Institute for Personalized Medicine ( email )

4505 S. Maryland Parkway
Las Vegas, NV 89154
United States

Nevada Center for Bioinformatics ( email )

1664 N. Virginia St
Reno, NV 89557
United States

Joel Sevinsky

THEIAGEN CONSULTING ( email )

1745 SHEA CENTER DRIVE
SUITE 400
HIGHLANDS RANCH, CO 80129
United States

Paul Hartley

University of Nevada, Reno ( email )

1664 N. Virginia St
Reno, NV 89557
United States

Heather Kerwin

WASHOE COUNTY HEALTH DISTRICT ( email )

Natalie Crawford

RENOWN HEALTH ( email )

Andrew Gorzalski

University of Nevada, Reno - NEVADA STATE PUBLIC HEALTH LABORATORY ( email )

1660 N. VIRGINIA ST.
RENO, NV 89521
United States

Christopher Laverdure

University of Nevada, Reno - NEVADA STATE PUBLIC HEALTH LABORATORY ( email )

1660 N. VIRGINIA ST.
RENO, NV 89521
United States

Subhash Verma

University of Nevada, Reno - School of Medicine ( email )

Cyprian Rossetto

University of Nevada, Reno - School of Medicine ( email )

David Jackson

WASHOE COUNTY SHERIFF'S FORENSIC SCIENCE DIVISION ( email )

Megan Farrell

WASHOE COUNTY SHERIFF'S FORENSIC SCIENCE DIVISION ( email )

Stephanie Van Hooser

University of Nevada, Reno - NEVADA STATE PUBLIC HEALTH LABORATORY ( email )

1660 N. VIRGINIA ST.
RENO, NV 89521
United States

Mark Pandori (Contact Author)

University of Nevada, Reno - Nevada State Public Health Laboratory ( email )

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