lancet-header

Preprints with The Lancet is part of SSRN´s First Look, a place where journals identify content of interest prior to publication. Authors have opted in at submission to The Lancet family of journals to post their preprints on Preprints with The Lancet. The usual SSRN checks and a Lancet-specific check for appropriateness and transparency have been applied. Preprints available here are not Lancet publications or necessarily under review with a Lancet journal. These preprints are early stage research papers that have not been peer-reviewed. The findings should not be used for clinical or public health decision making and should not be presented to a lay audience without highlighting that they are preliminary and have not been peer-reviewed. For more information on this collaboration, see the comments published in The Lancet about the trial period, and our decision to make this a permanent offering, or visit The Lancet´s FAQ page, and for any feedback please contact preprints@lancet.com.

Synergistic Effect of Quercetin and Vitamin C Against COVID-19: Is a Possible Guard for Front Liners

19 Pages Posted: 16 Nov 2020

See all articles by Bengu Arslan

Bengu Arslan

Istanbul Kanuni Sultan Suleyman Training and Research Hospital - Department of Pediatric Nutrition and Metabolism Clinics

Nurcan Ucuncu Ergun

Istanbul Kanuni Sultan Suleyman Training and Research Hospital - Department of Pediatric Nutrition and Metabolism Clinics

Seyma Topuz

Istanbul Kanuni Sultan Suleyman Training and Research Hospital - Department of Pediatric Nutrition and Metabolism Clinics

Seda Yilmaz Semerci

Istanbul Kanuni Sultan Suleyman Training and Research Hospital - Department of Neonatology

Nurettin Suner

Istanbul Kanuni Sultan Suleyman Training and Research Hospital - Department of General Medicine

Ali Kocatas

Istanbul Kanuni Sultan Suleyman Training and Research Hospital - Department of General Surgery

Hasan Onal

Istanbul Kanuni Sultan Suleyman Training and Research Hospital - Department of Pediatric Nutrition and Metabolism Clinics

More...

Abstract

Background: While waiting for vaccine, hygiene measures, social distance and personal protective equipment are the only basic protection against Novel Coronavirus. However, these are not sufficient to protect healthcare workers.This study aimed to evaluate if quercetin and vitamin C could be protective against Novel Coronavirus.

Methods: In prophylaxis group supplementation containing 500mg of quercetin, 500mg of vitamin C and 50mg of  bromelain (QCB) was initiated daily in 2 divided doses for 71 healthcare workers working in areas with high risk of COVID-19, whereas 42 were determined as control group without using supplements.A maximum period of follow-up was determined as 120 days.Termination of use of QCB earlier or having a Coronavirus infection was considered as final point.At the end rapid diagnostic test used to detect immunoglobulin positivity.

Results: A total of 113 persons included. No significant difference detected between groups in terms of other features.Mean age of QCB group was 39.0 ± 8.8 years and control group was 32.9 ± 8.7.Average follow-up period for the QCB group was 113 days, and for the control group, 118, during follow-up period, 1 healthcare worker in QCB group and 9 out of 42 in control group had COVID-19.One of cases was asymptomatic, while others were not.Transmission risk hazard ratio whose did not receive QCB was 12.04 (95% Confidence interval= 1.26-115.06, P = 0.031).No significant effect of gender, smoking, antihypertensive medication exposure and having chronic disease on rate of transmission.

Conclusion: This study revealed that QCB was protective for healthcare workers.Trial registration NCT04377789

Funding: None to disclose

Declaration of Interest: None to disclose

Ethical Approval Statement: This study was approved by the ethical approval team at Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi.

Keywords: COVID-19, healthcare workers, prophylaxis, quercetin, vitamin C

Suggested Citation

Arslan, Bengu and Ucuncu Ergun, Nurcan and Topuz, Seyma and Yilmaz Semerci, Seda and Suner, Nurettin and Kocatas, Ali and Onal, Hasan, Synergistic Effect of Quercetin and Vitamin C Against COVID-19: Is a Possible Guard for Front Liners. Available at SSRN: https://ssrn.com/abstract=3682517 or http://dx.doi.org/10.2139/ssrn.3682517

Bengu Arslan

Istanbul Kanuni Sultan Suleyman Training and Research Hospital - Department of Pediatric Nutrition and Metabolism Clinics ( email )

Istanbul
Turkey

Nurcan Ucuncu Ergun

Istanbul Kanuni Sultan Suleyman Training and Research Hospital - Department of Pediatric Nutrition and Metabolism Clinics ( email )

Istanbul
Turkey

Seyma Topuz

Istanbul Kanuni Sultan Suleyman Training and Research Hospital - Department of Pediatric Nutrition and Metabolism Clinics ( email )

Istanbul
Turkey

Seda Yilmaz Semerci

Istanbul Kanuni Sultan Suleyman Training and Research Hospital - Department of Neonatology ( email )

Istanbul
Turkey

Nurettin Suner

Istanbul Kanuni Sultan Suleyman Training and Research Hospital - Department of General Medicine ( email )

Istanbul
Turkey

Ali Kocatas

Istanbul Kanuni Sultan Suleyman Training and Research Hospital - Department of General Surgery ( email )

Istanbul
Turkey

Hasan Onal (Contact Author)

Istanbul Kanuni Sultan Suleyman Training and Research Hospital - Department of Pediatric Nutrition and Metabolism Clinics ( email )

Istanbul
Turkey

Click here to go to TheLancet.com

Paper statistics

Abstract Views
21,878
Downloads
2,404
PlumX Metrics