4-Acylhydrazone-5-Pyrazolones and Their Zinc(II) Metal Complexes: Synthesis, Characterization, Crystal Feature and Antimalarial Activity

25 Pages Posted: 31 Aug 2020

See all articles by Irfan Shaikh

Irfan Shaikh

affiliation not provided to SSRN

Rajendrasinh N. Jadeja

Maharaja Sayajirao University of Baroda (MS)

Patel R. K.

Hemchandracharya North Gujarat University

Vishal Mevada

affiliation not provided to SSRN

Abstract

Two novel 4-acylhydrazone-5-pyrazolones (L1=(Z)-N'-((4-chlorophenyl)(3-methyl-5-oxo-1-(p-tolyl)-4,5-dihydro-1H-pyrazol-4-yl)methylene)benzohydrazide and L2 = (Z)-N'-((4-chloro phenyl )(1-(3-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)methylene)benzohydrazide) were synthesized from 4-acyl-5-pyrazolone and benzoyl hydrazide and assessed for in silico and in vitro antimalarial activity. Synthesized one binary Zinc(II) complex 1 [Zn(L1)2]from L1. Two mixed ligands complexes 2 [Zn(L2)(bpy)(OAc)]EtOH and 3 [Zn(L2)(phen)(H2O)] were synthesized from L2 with 2,2’-bipyridine and 1, 10-phenanthroline, respectively. Ligands and complexes were characterized by 1H NMR, FT-IR, UV-Vis, Single crystal X-ray diffraction and conductance measurement. All compounds displayed decent outcomes in invitro antimalarial activity.

Keywords: 4-Acylhydrazone-5-pyrazolone, In silico & in vitro antimalarial, Mixed ligand complex, Single crystal, zinc(II) complexes

Suggested Citation

Shaikh, Irfan and Jadeja, Rajendrasinh N. and R. K., Patel and Mevada, Vishal, 4-Acylhydrazone-5-Pyrazolones and Their Zinc(II) Metal Complexes: Synthesis, Characterization, Crystal Feature and Antimalarial Activity. Available at SSRN: https://ssrn.com/abstract=3682799

Irfan Shaikh (Contact Author)

affiliation not provided to SSRN

Rajendrasinh N. Jadeja

Maharaja Sayajirao University of Baroda (MS) ( email )

Vadodara
Nizampura
Baroda, Gujarat 390001
India

Patel R. K.

Hemchandracharya North Gujarat University ( email )

Patan 384265
India

Vishal Mevada

affiliation not provided to SSRN

No Address Available

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