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Minute-Encoding Neurons in Hippocampal-Striatal Circuits

49 Pages Posted: 1 Oct 2020 Publication Status: Under Review

See all articles by Takuya Sasaki

Takuya Sasaki

University of Tokyo - Graduate School of Pharmaceutical Sciences

Yu Shikano

University of Tokyo - Graduate School of Pharmaceutical Sciences

Yuji Ikegaya

University of Tokyo - Graduate School of Pharmaceutical Sciences

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Abstract

Animals process temporal information in an ever-changing environment, but the neuronal mechanisms of this process, especially on timescales longer than seconds, remain unresolved. Here, we designed a hippocampus-dependent task in which rats prospectively increased their reward-seeking behavior over a duration of minutes. During this timing behavior, hippocampal and striatal neurons represented successive time points on the order of minutes. These minute-encoding patterns progressively developed as the rats learned a time-reward relationship, and the patterns underwent flexible scaling in parallel with timing behavior. These observations suggest a neuronal basis in the hippocampal-striatal circuits that enables temporal processing and formation of episodic memory on a timescale of minutes.

Keywords: time, minutes, hippocampus, striatum, encoding

Suggested Citation

Sasaki, Takuya and Shikano, Yu and Ikegaya, Yuji, Minute-Encoding Neurons in Hippocampal-Striatal Circuits. Available at SSRN: https://ssrn.com/abstract=3684131 or http://dx.doi.org/10.2139/ssrn.3684131
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Takuya Sasaki (Contact Author)

University of Tokyo - Graduate School of Pharmaceutical Sciences ( email )

Tokyo, 113-0033
Japan

Yu Shikano

University of Tokyo - Graduate School of Pharmaceutical Sciences ( email )

Tokyo, 113-0033
Japan

Yuji Ikegaya

University of Tokyo - Graduate School of Pharmaceutical Sciences ( email )

Tokyo, 113-0033
Japan

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