Minute-Encoding Neurons in Hippocampal-Striatal Circuits
49 Pages Posted: 1 Oct 2020 Publication Status: Under ReviewMore...
Animals process temporal information in an ever-changing environment, but the neuronal mechanisms of this process, especially on timescales longer than seconds, remain unresolved. Here, we designed a hippocampus-dependent task in which rats prospectively increased their reward-seeking behavior over a duration of minutes. During this timing behavior, hippocampal and striatal neurons represented successive time points on the order of minutes. These minute-encoding patterns progressively developed as the rats learned a time-reward relationship, and the patterns underwent flexible scaling in parallel with timing behavior. These observations suggest a neuronal basis in the hippocampal-striatal circuits that enables temporal processing and formation of episodic memory on a timescale of minutes.
Keywords: time, minutes, hippocampus, striatum, encoding
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