To Study the Effect of Unconventional Treatment Protocol on COVID-19 Patients in Delhi Using Artificial Intelligence Based Methods.

53 Pages Posted: 17 Sep 2020

See all articles by Kamal Rawal

Kamal Rawal

Amity University - Amity Institute of Biotechnology

Bipin Jethani

Nehru Homeopathic Medical College and Hospital

Preeti P.

Amity University - Amity Institute of Biotechnology

Kartik Mishra

Amity University - Amity Institute of Biotechnology

Nath Swarsat

Amity University - Amity Institute of Biotechnology

Akshit Gupta

Amity University - Amity Institute of Biotechnology

Robin Sinha

Amity University - Amity Institute of Biotechnology

Akshat Gupta

Amity University - Amity Institute of Biotechnology

Meeta Gupta

Government of NCT of Delhi

Raj Kumar Manchanda

Government of NCT of Delhi

Date Written: August 28, 2020

Abstract

COVID-19 has affected over 24 million patients with over 8 lacs deaths worldwide. Till date, no specific drug or vaccine has been proven effective for the treatment of SARS-CoV-2 patients. In a recent observational cohort study conducted at Delhi Government designated COVID hospital on 221 patients, important facts have emerged indicating the benefits of using unconventional treatment protocol (consisting of combination of homeopathic medicines, allopathic medicines & non-pharmacological interventions) in COVID-19 situation. The interdisciplinary team of doctors and scientists have found that out of 221 COVID-19 positive patients (diagnosed with RT-PCR), 169 patients were clinically classified as patients of mild category and 21 were labeled as moderate whereas 31 patients were asymptomatic. 170 patients were treated with either homeopathic medicines, allopathic medicines or the combination of both. The unconventional treatment protocol combining homeopathic medicines and allopathic systems showed rapid improvement in clinical condition. We found that fever (temperature) was reduced to normal on an average of 7.45 ± 5.19 days. The treatment outcome of this study showed better results when compared with control datasets obtained from independent studies published earlier. All the patients were discharged on an average of 9.29 ± 3.52 days. The mortality rate was zero and there were no adverse events for the patients. Apart from temperature and fever, symptoms such as cough, sore throat, myalgia, & dyspnea also improved significantly in the patients enrolled in this study. The average time for clinical improvement was significantly better than previously published clinical studies on COVID-19 patients in independent hospitals. This study indicates that the use of unconventional treatment protocol can emerge as an effective treatment option for COVID-19 patients. Despite the challenges (i.e. limited availability of high quality clinical data), we generated a machine learning model for semi-automated prediction of potential treatments (i.e. medicines, non-pharmacological interventions) that should be prescribed to the patient based on the time dependent clinical features, comorbidities, & demographic profiling. Further, efforts are underway to include additional clinical data from COVID19 patients to provide a robust and accurate machine learning based prescription system.

Note: Funding: No separate financial support was sought for the conduct of the study.

Ethical Approval: The ethical committee of Delhi government hospital approved this study. Informed consent for the treatment using unconventional medicines against COVID-19 was signed by all the patients. Patients’ privacy was completely protected throughout the study.

Declaration of Interest: All the contributors (except VJ, MG and RKM) are full time students or employees at Amity Institute of Biotechnology, Amity University Uttar Pradesh. VJ, MG and RKM are full time staff employed by the Government of NCT of Delhi. Dr. Kamal Rawal acknowledges the support provided by DBT, Government of India for the grant of Department of Biotechnology, Ministry of Science and Technology, Government of India (Grant Id: BT/PR17252/BID/7/708/2016), SERB, Department of Science Technology for their grant on study of repurposed drugs on COVID-19 as well as Ministry of AYUSH.

Keywords: SARS-CoV-2, COVID-19, Homeopathy, Antibiotics, Machine Learning

Suggested Citation

Rawal, Kamal and Jethani, Bipin and P., Preeti and Mishra, Kartik and Swarsat, Nath and Gupta, Akshit and Sinha, Robin and Gupta, Akshat and Gupta, Meeta and Manchanda, Raj Kumar, To Study the Effect of Unconventional Treatment Protocol on COVID-19 Patients in Delhi Using Artificial Intelligence Based Methods. (August 28, 2020). Available at SSRN: https://ssrn.com/abstract=3685705 or http://dx.doi.org/10.2139/ssrn.3685705

Kamal Rawal (Contact Author)

Amity University - Amity Institute of Biotechnology ( email )

J-3 Block, Amity University Campus
Sector – 125
Noida
India

Bipin Jethani

Nehru Homeopathic Medical College and Hospital

India

Preeti P.

Amity University - Amity Institute of Biotechnology

J-3 Block, Amity University Campus
Sector – 125
Noida
India

Kartik Mishra

Amity University - Amity Institute of Biotechnology

J-3 Block, Amity University Campus
Sector – 125
Noida
India

Nath Swarsat

Amity University - Amity Institute of Biotechnology

J-3 Block, Amity University Campus
Sector – 125
Noida
India

Akshit Gupta

Amity University - Amity Institute of Biotechnology

J-3 Block, Amity University Campus
Sector – 125
Noida
India

Robin Sinha

Amity University - Amity Institute of Biotechnology

J-3 Block, Amity University Campus
Sector – 125
Noida
India

Akshat Gupta

Amity University - Amity Institute of Biotechnology

J-3 Block, Amity University Campus
Sector – 125
Noida
India

Meeta Gupta

Government of NCT of Delhi

India

Raj Kumar Manchanda

Government of NCT of Delhi

India

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