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The Risk of Cardiovascular Disease Among Ovarian Cancer Survivors

23 Pages Posted: 28 Oct 2020

See all articles by Qingqing Hu

Qingqing Hu

University of Utah - Huntsman Cancer Institute

Chun-Pin Chang

University of Utah - Huntsman Cancer Institute

Brenna Blackburn

University of Utah - Huntsman Cancer Institute

David Baraghoshi

University of Utah - Huntsman Cancer Institute

Sarah Abdelaziz

University of Utah - Huntsman Cancer Institute

Kerry Rowe

Intermountain Healthcare

John Snyder

Intermountain Healthcare

Vikrant Deshmukh

University of Utah - Health Sciences Center

Michael Newman

University of Utah - Health Sciences Center

Alison Fraser

University of Utah - Pedigree and Population Resource

Ken Smith

University of Utah - Pedigree and Population Resource

Yuan-Chin Amy Lee

University of Utah - Huntsman Cancer Institute

Lisa Gren

University of Utah - Division of Pubic Health

Christina Porucznik

University of Utah - Division of Pubic Health

Jennifer Anne Doherty

University of Utah - Huntsman Cancer Institute

Joseph Stanford

University of Utah - Division of Pubic Health

N. Lynn Henry

University of Michigan at Ann Arbor - Rogel Cancer Center, Division of Hematology/Oncology

Mia Hashibe

University of Utah - Huntsman Cancer Institute

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Abstract

Background: Very few studies have investigated cardiovascular disease (CVD) risk among ovarian cancer survivors in a population-based study. We aimed to estimate CVD risk among ovarian cancer survivors compared to women from the general population in a population-based study.

Methods: A cohort of 1,271 patients with ovarian cancer diagnosed from 1996 to 2012 in the Utah Cancer Registry and 5,289 age-matched women from the general population in the Utah Population Database was identified. CVD outcomes were available in electronic medical records and statewide healthcare facilities data. Cox Proportional Hazards models were used to estimate hazard ratios (HRs) for CVD at 1-5 years and >5 years after the index date.

Findings:  Increased risks were observed 1-5 years after cancer diagnosis for ovarian cancer survivors in comparison with the general population for hypertension (HR=1·14, 95% CI, 1·01-1·29), cerebrovascular disease (HR=1·42, 95% CI, 1·06-1·89), and diseases of the heart (HR=1·81, 95% CI, 1·60-2·04), the arteries (HR=1·97, 95% CI, 1·67-2·33), and the veins and lymphatics (HR=2·75, 95% CI, 2·36-3·22). Elevated risks were still observed for diseases of the arteries (HR=1·31, 95% CI, 1·06-1·61) and the veins and lymphatics (HR=1·80, 95% CI, 1·48-2·18) >5 years after cancer diagnosis.  

Interpretation:  Ovarian cancer survivors had higher risks of several CVD outcomes compared with women from the general population. The results support the consideration of monitoring and/or initiation of primary prevention for CVD outcomes among ovarian cancer survivors.

Funding: This work was supported by a grant from the NCI (R21 CA185811), the Marian Bishop Award from the Department of Family and Preventive Medicine at the University of Utah and the NCRR grant, “Sharing Statewide Health Data for Genetic Research” (R01 RR021746, G. Mineau, PI) with additional support from the Utah State Department of Health and the University of Utah.

Declaration of Interests: None reported.

Ethics Approval Statement: We obtained approval from the University of Utah’s Resource for Genetic and Epidemiologic Research (UPDB oversight committee) and the University of Utah Institutional Review Board.

Keywords: Ovarian cancer, population-based, cardiovascular disease

Suggested Citation

Hu, Qingqing and Chang, Chun-Pin and Blackburn, Brenna and Baraghoshi, David and Abdelaziz, Sarah and Rowe, Kerry and Snyder, John and Deshmukh, Vikrant and Newman, Michael and Fraser, Alison and Smith, Ken and Lee, Yuan-Chin Amy and Gren, Lisa and Porucznik, Christina and Doherty, Jennifer Anne and Stanford, Joseph and Henry, N. Lynn and Hashibe, Mia, The Risk of Cardiovascular Disease Among Ovarian Cancer Survivors. Available at SSRN: https://ssrn.com/abstract=3697989 or http://dx.doi.org/10.2139/ssrn.3697989

Qingqing Hu

University of Utah - Huntsman Cancer Institute

2000 Cir of Hope Dr
Salt Lake City, UT 84103
United States

Chun-Pin Chang

University of Utah - Huntsman Cancer Institute

2000 Cir of Hope Dr
Salt Lake City, UT 84103
United States

Brenna Blackburn

University of Utah - Huntsman Cancer Institute ( email )

2000 Cir of Hope Dr
Salt Lake City, UT 84103
United States

David Baraghoshi

University of Utah - Huntsman Cancer Institute ( email )

2000 Cir of Hope Dr
Salt Lake City, UT 84103
United States

Sarah Abdelaziz

University of Utah - Huntsman Cancer Institute

2000 Cir of Hope Dr
Salt Lake City, UT 84103
United States

Kerry Rowe

Intermountain Healthcare

Salt Lake City, UT
United States

John Snyder

Intermountain Healthcare

Salt Lake City, UT
United States

Vikrant Deshmukh

University of Utah - Health Sciences Center ( email )

1645 E. Campus Center
Salt Lake City, UT 84112
United States

Michael Newman

University of Utah - Health Sciences Center

1645 E. Campus Center
Salt Lake City, UT 84112
United States

Alison Fraser

University of Utah - Pedigree and Population Resource

2000 Cir of Hope Dr
Salt Lake City, UT 84103
United States

Ken Smith

University of Utah - Pedigree and Population Resource

2000 Cir of Hope Dr
Salt Lake City, UT 84103
United States

Yuan-Chin Amy Lee

University of Utah - Huntsman Cancer Institute ( email )

2000 Cir of Hope Dr
Salt Lake City, UT 84103
United States

Lisa Gren

University of Utah - Division of Pubic Health ( email )

Salt Lake City, UT
United States

Christina Porucznik

University of Utah - Division of Pubic Health ( email )

Salt Lake City, UT
United States

Jennifer Anne Doherty

University of Utah - Huntsman Cancer Institute ( email )

2000 Cir of Hope Dr
Salt Lake City, UT 84103
United States

Joseph Stanford

University of Utah - Division of Pubic Health ( email )

Salt Lake City, UT
United States

N. Lynn Henry

University of Michigan at Ann Arbor - Rogel Cancer Center, Division of Hematology/Oncology

500 S. State Street
Ann Arbor, MI 48109
United States

Mia Hashibe (Contact Author)

University of Utah - Huntsman Cancer Institute ( email )

2000 Cir of Hope Dr
Salt Lake City, UT 84103
United States

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