Synthesis, Characterization and Biological Studies of Nickel ( Ii) and Zinc ( Ii) Complexes with Mono - and Di - Bromo Substituted Schiff Base Ligands

30 Pages Posted: 24 Sep 2020

See all articles by Bussaba Pinchaipat

Bussaba Pinchaipat

Naresuan University

Teerawat Khudkham

affiliation not provided to SSRN

Sutthida Wongsuwan

affiliation not provided to SSRN

Ratanon Chotima

affiliation not provided to SSRN

Kittipong Chainok

affiliation not provided to SSRN

Taweesak Pila

affiliation not provided to SSRN

Abstract

Transition metal complexes of nickel(II) and zinc(II) with 5-bromo- N -(8-quinolyl)salicylaldimine (HqsalBr, HL 1 ) and 3,5-dibromo- N -(8-quinolyl)salicylaldimine (HqsalBr 2 , HL 2 ) have been synthesized and successfully characterized using several techniques: IR, 1 H-NMR, mass spectrometry and thermogravimetric analysis (TGA). The molecular structures of nickel(II) and zinc(II) complexes with HL 2 were determined by single crystal X-Ray crystallography. Ligands HL 1 and HL 2 both act as a tridentate ligand and coordinate to metal ion center via deprotonated hydroxyl oxygen atom, nitrogen of azomethine functional group and nitrogen of quinoline substituent. The interaction of these complexes with DNA was investigated using calf thymus DNA (CT-DNA) in which the studies by electronic absorption and luminescence titrations reveal that DNA binding mode of the complexes is intercalation. All the synthesized complexes provide great values of binding constant (K b ) and these results are consistent with the quenching capability defined by quenching constant values (K q ). Amongst the synthesized complexes, zinc(II) with ligand HL 2 complex, [Zn(qsalBr) 2 ], exhibits the most superior ability in the interaction with CT-DNA and the verification mode of binding by the competitive reaction with ethidium bromide (EB) also indicates the strongest intercalation by such complex. Additionally, ligands and complexes were also examined in anti-lung cancer activity against A549 cell line and compared with standard compounds, Etoposide and Cisplatin.

Keywords: Schiff base, Nickel(II) complexes, Zinc(II) complexes, Crystal structure, Anti-lung cancer

Suggested Citation

Pinchaipat, Bussaba and Khudkham, Teerawat and Wongsuwan, Sutthida and Chotima, Ratanon and Chainok, Kittipong and Pila, Taweesak, Synthesis, Characterization and Biological Studies of Nickel ( Ii) and Zinc ( Ii) Complexes with Mono - and Di - Bromo Substituted Schiff Base Ligands. Available at SSRN: https://ssrn.com/abstract=3698599

Bussaba Pinchaipat (Contact Author)

Naresuan University ( email )

99 Moo 9 Tambon Tha Pho
Muang, Phitsanulok 65000
Thailand

Teerawat Khudkham

affiliation not provided to SSRN

No Address Available

Sutthida Wongsuwan

affiliation not provided to SSRN

No Address Available

Ratanon Chotima

affiliation not provided to SSRN

No Address Available

Kittipong Chainok

affiliation not provided to SSRN

No Address Available

Taweesak Pila

affiliation not provided to SSRN

No Address Available

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