Longitudinal Observation of Antibody Dynamics in Three COVID-19 Patient against Four Structural SARS-CoV2 Proteins

19 Pages Posted: 7 Oct 2020

See all articles by Nihad Adnan

Nihad Adnan

Jahangirnagar University

Mohd. Raeed Jamiruddin

Brac University

Md. Ahsanul Haq

Gonoshasthaya RNA Biotech Limited

Shahad Saif Khandker

Gonoshasthaya RNA Biotech Limited

Nowshin Jahan

RNA Biotech Limited

Tamanna Ali

Gonoshasthaya RNA Biotech Limited

Mumtarin Jannat Oishee

Gonoshasthaya RNA Biotech Limited

Zafrullah Chowdhury

Gonoshasthaya Kendra

Mohib Ullah Khondoker

Gonoshasthaya Samaj Vittik Medical College

Bijon Kumar Sil

Gono University

Date Written: October 3, 2020

Abstract

Proper understanding of antibody dynamics and persistence of neutralizing antibodies will provide us the knowledge required for designing successful vaccine. Disappearance of antibody, absence of humoral immunity activation, sporadic cases of reinfection emphasize the importance of longitudinal antibody dynamic against variable structural antigens. In this study, we followed the antibody dynamics of three subjects over a period of 120 days by analyzing 512 samples. Among the three subjects, subject-1 (S01), has had previous infection with SARS-CoV during the 2003 epidemic. During the study period, all the subjects presented COVID-19 like symptoms twice, firstly mild symptoms followed by severe symptoms presentation. The initial episode did not culminate with any antibody development other than mild development of IgG against SARS-CoV-2 nucleocapsid. The second episode was characterized with multifold increase in IgG antibodies against the four SARS-CoV-2 proteins, but varied among individuals for IgM and IgA. Antibody dynamics in S01 and S02 highly correlated while that of S03 slightly differed, which may have been due to the unsupervised medicine regimen S03 opted for during the study period. Interestingly, antibody development for all subjects highly correlated with the severity of the symptoms.

Note: Funding: No funding source.

Conflict of Interest: The authors declare that they have no competing interest.

Keywords: SARS-CoV-2, COVID-19, Serology, Seroprevalence, Antibody dynamics

Suggested Citation

Adnan, Nihad and Jamiruddin, Mohd. Raeed and Haq, Md. Ahsanul and Khandker, Shahad Saif and Jahan, Nowshin and Ali, Tamanna and Oishee, Mumtarin Jannat and Chowdhury, Zafrullah and Khondoker, Mohib Ullah and Sil, Bijon Kumar, Longitudinal Observation of Antibody Dynamics in Three COVID-19 Patient against Four Structural SARS-CoV2 Proteins (October 3, 2020). Available at SSRN: https://ssrn.com/abstract=3704264 or http://dx.doi.org/10.2139/ssrn.3704264

Nihad Adnan

Jahangirnagar University ( email )

Kalabagan Rd, Savar Union
Dhaka, 1342
Bangladesh

Mohd. Raeed Jamiruddin

Brac University ( email )

UB31004, 41 Mohakhali C/A
Department of Pharmacy
Dhaka, 1212
Bangladesh
+8801732943631 (Phone)

HOME PAGE: http://www.bracu.ac.bd

Md. Ahsanul Haq

Gonoshasthaya RNA Biotech Limited ( email )

Mirzanagar, Ashulia, Savar
Dhaka, 1344
Bangladesh
+8801929409044 (Phone)

Shahad Saif Khandker

Gonoshasthaya RNA Biotech Limited ( email )

Mirzanagar, Ashulia, Savar
Dhaka, 1344
Bangladesh
+8801686286072 (Phone)

Nowshin Jahan

RNA Biotech Limited ( email )

House#42, Road#1, Block A,
Niketan, Gulshan-1
Dhaka, 1212
Bangladesh
+8801791318098 (Phone)

Tamanna Ali

Gonoshasthaya RNA Biotech Limited ( email )

Mirzanagar, Ashulia, Savar
Dhaka, 1344
Bangladesh
+8801914551398 (Phone)

Mumtarin Jannat Oishee

Gonoshasthaya RNA Biotech Limited ( email )

Mirzanagar, Ashulia, Savar
Dhaka, 1344
Bangladesh
+8801733240684 (Phone)

Zafrullah Chowdhury

Gonoshasthaya Kendra ( email )

Mirjanagar, Asulia, Savar
Dhaka, 1344
Bangladesh
+8801534001230 (Phone)

Mohib Ullah Khondoker

Gonoshasthaya Samaj Vittik Medical College ( email )

Mirzanagar, Savar
Dhaka, 1344
Bangladesh
+8801711541813 (Phone)

Bijon Kumar Sil (Contact Author)

Gono University ( email )

Nolam, Mirzanagar,
Ashulia, Savar
Dhaka, 1344
Bangladesh
+8801772564593 (Phone)

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