Tumor Cell Survival Secrets

5 Pages Posted: 21 Nov 2020

See all articles by Junlan Zhu

Junlan Zhu

affiliation not provided to SSRN

Alexandra Zamaro

Institute of Physiology, National Academy of Sciences, Minsk, Belarus

Tatiana Kuznetsova

National Research University Higher School of Economics

Stanislav Koulchitsky

University of Liège

Kestutis Suziedelis

affiliation not provided to SSRN

Yulya Takalchyk

affiliation not provided to SSRN

Yuri Shanko

affiliation not provided to SSRN

Vladimir Kulchitsky

Institute of Physiology, National Academy of Sciences, Minsk, Belarus

Date Written: October 4, 2020

Abstract

Experiments were performed on 28 sexually mature Wistar rats divided into two equal groups. Rats were fixed in stereotactic apparatus and received 2.8×105 C6 glioma cells in 20 μl of F10 medium locally into frontal region of brain under ketamine-xylazine-acepromazine anesthesia. One group of rats (n=14) was implanted with 40×104 MSCs in 40 μl of low glucose DMEM medium into submucosa of nasal cavity. Further, only rats from this group received 40×104 mesenchymal stem cells (MSCs) intranasally in the form of a spray on a weekly basis. All 14 rats from the second group died within two months. Rats with implanted MSCs started to die in two and a half months. Two rats lived up to 8.5 months. One of these rats was decapitated, brain slices stained with hematoxylin-eosin and Nissl – and no tumor cells were found. A connective tissue scar was found at the site of injection.

Keywords: Glioma, Stem Cells, Exosomes, Treatment

Suggested Citation

Zhu, Junlan and Zamaro, Alexandra and Kuznetsova, Tatiana and Koulchitsky, Stanislav and Suziedelis, Kestutis and Takalchyk, Yulya and Shanko, Yuri and Kulchitsky, Vladimir, Tumor Cell Survival Secrets (October 4, 2020). Available at SSRN: https://ssrn.com/abstract=3704741 or http://dx.doi.org/10.2139/ssrn.3704741

Junlan Zhu

affiliation not provided to SSRN

Alexandra Zamaro (Contact Author)

Institute of Physiology, National Academy of Sciences, Minsk, Belarus ( email )

28 Akademicheskaya Street
Minsk, 220072
Belarus
220072 (Fax)

Tatiana Kuznetsova

National Research University Higher School of Economics ( email )

Myasnitskaya street, 20
Moscow, Moscow 119017
Russia

Stanislav Koulchitsky

University of Liège ( email )

B-4000 Liege
Belgium

Kestutis Suziedelis

affiliation not provided to SSRN

Yulya Takalchyk

affiliation not provided to SSRN

Yuri Shanko

affiliation not provided to SSRN

Vladimir Kulchitsky

Institute of Physiology, National Academy of Sciences, Minsk, Belarus ( email )

28 Akademicheskaya Street
Minsk, 220072
Belarus

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