Formulation and Evaluation of Film Forming Gel of Mometasone Furoate

15 Pages Posted: 23 Nov 2020

See all articles by Deattu N

Deattu N

Madras Medical College - College of Pharmacy

Sunitha.P.G.

Madras Medical College; Madras Medical College

Jerad Suresh

Madras Medical College - Department of Pharmaceutical Chemistry

Banu Priya S

Madras Medical College - Department of Pharmaceutical Chemistry

Date Written: October 4, 2020

Abstract

The present investigation was aimed to formulate and evaluate film forming gel of Mometasone furoate by dispersion method with HPMC E15, Carbomer 934 and propylene glycol to increase the drug penetration through the skin. The gelling agent was dispersed in solvent with stirring at 1200 RPM for 30mins. Drug was dissolved in non aqueous solvent followed by addition of preservative and flavouring agent. The prepared formulation was evaluated for invitro diffusion study release, spreadability etc. All formulation showed drug release from 51.79% to 97.89%, good homogeneity and gel was easily spreadable. Optimized formulation showed enhanced rate of diffusion, drug release and was found suitable for sustained release with good stability.

Keywords: Acetone; HPMC E15; Mometasone furoate; Propylene glycol

Suggested Citation

N, Deattu and P.G., Sunitha and Suresh, Jerad and S, Banu Priya, Formulation and Evaluation of Film Forming Gel of Mometasone Furoate (October 4, 2020). Available at SSRN: https://ssrn.com/abstract=3705424 or http://dx.doi.org/10.2139/ssrn.3705424

Deattu N (Contact Author)

Madras Medical College - College of Pharmacy ( email )

India

Sunitha P.G.

Madras Medical College ( email )

India

Madras Medical College ( email )

India

Jerad Suresh

Madras Medical College - Department of Pharmaceutical Chemistry ( email )

India

Banu Priya S

Madras Medical College - Department of Pharmaceutical Chemistry ( email )

India

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