Homocysteine and the SARS-CoV-2 Coronavirus – The X Factor of Severe Disease and Death

6 Pages Posted: 15 Oct 2020 Last revised: 19 Oct 2020

Date Written: October 10, 2020


Homocysteine (Hcy) is a natural, non-essential amino acid formed by the de-methylation of methionine. Pathologic elevations occur in many chronic conditions, particularly the cardiovascular conditions common with aging, and in SARS-Cov2. The most common co-existing morbidities, hypertension, cardiovascular disease, and diabetes are all strongly associated with elevated levels of Homocysteine. Homocysteine’s effects include potential mechanisms for triggering severe COVID-19 disease, or preventing its control. For instance, SARS-CoV2 enters cells through its spike proteins that attach to the Angiotensin Converting Enzyme 2 (ACE2) cellular receptors to form a tunnel through which the virus enters the celli. Homocysteine, in attaching to the enzyme, may inhibit its attachment to the receptors and allow more virus to enter the cells. High homocysteine levels increase inflammatory cytokines that are over-produced in cytokine release syndrome or “cytokine storm”, increase endothelial dysfunction, inhibit nitric oxide synthesis, and lead to thrombus formation. All of these pathologies are hallmarks of severe SARS-Cov2.

Note: Funding: None to declare.

Declaration of Interests: None to declare.

Keywords: homocysteine, COVID-19, SARS-CoV2, co-existing morbities, hypertension, cardiovascular, diabetes, obesity, cytokine release, thrombus, thromboembolism, respiratory distress, folic acid, folate, cobalamin, pyridoxine

Suggested Citation

Lord, Nancy and Ruwart, Mary J, Homocysteine and the SARS-CoV-2 Coronavirus – The X Factor of Severe Disease and Death (October 10, 2020). Available at SSRN: https://ssrn.com/abstract=3708654 or http://dx.doi.org/10.2139/ssrn.3708654

Mary J Ruwart

Independent ( email )

Do you have negative results from your research you’d like to share?

Paper statistics

Abstract Views
PlumX Metrics