Search for Natural Alkaloids As SARS-CoV-2 Proteas and RdRp Inhibitors: A Docking-Based Study

8 Pages Posted: 27 Oct 2020

See all articles by Arijit Bag

Arijit Bag

Indian Institute of Science Education and Research (IISER); Maulana Abul Kalam Azad University of Technology

Abhrajit Bag

Malancha Shishu Shiksha Niketan

Date Written: October 10, 2020

Abstract

To find an immediately applicable drug for the treatment of COVID-19 positive patients, a plausible life cycle of this virus is proposed from the analysis of a few case reports. Based on this proposal and symptomatic similarities, a few common drug-molecules are tested as a protease inhibitor and RNA-dependent RNA polymarase (RdRp) inhibitor of the SARS-CoV-2 virus using the COVID-19 Docking Server. It is observed that anisotine and vasicoline of Justicia adhatoda and Pemirolast are very good inhibitors. As all these three compounds are market available drugs, an immediate clinical trial is plausible which may lead to the golden success against the present pandemic. We prescribed different drugs for different purposes and stages of viral infection.

Note: Funding: None to declare.

Declaration of Interests: None to declare.

Keywords: COVID-19, Structure of SARS-CoV-2, Infection mechanism of COVID-19, Model drugs for COVID-19, Docking study

JEL Classification: z0

Suggested Citation

Bag, Arijit and Bag, Abhrajit, Search for Natural Alkaloids As SARS-CoV-2 Proteas and RdRp Inhibitors: A Docking-Based Study (October 10, 2020). Available at SSRN: https://ssrn.com/abstract=3708828 or http://dx.doi.org/10.2139/ssrn.3708828

Arijit Bag (Contact Author)

Indian Institute of Science Education and Research (IISER) ( email )

Mohanpur
Nadia, IN WEST BENGAL 743371
India

Maulana Abul Kalam Azad University of Technology ( email )

India
09735219451 (Phone)
741249 (Fax)

Abhrajit Bag

Malancha Shishu Shiksha Niketan ( email )

Simhat
Haringhata
Nadia, West Bengal 741249
India

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