PHTALOX® Mouthwash as An Option to Reduce Clinical Symptoms of COVID-19: Case Series

6 Pages Posted: 25 Nov 2020

See all articles by Bernardo da Orcina

Bernardo da Orcina

University of São Paulo (USP)

Fabiano Vieira Vilhena

TRIALS – Oral Health and Technologies

Rodrigo Cardoso de Oliveira

University of São Paulo (USP)

Lucas Marques da Costa Alves

Hospital Estadual de Bauru

Koiti Araki

University of São Paulo (USP)

Sérgio Hiroshi Toma

University of São Paulo (USP)

Mariana Schutzer Ragghianti Zangrando

University of São Paulo (USP)

Paulo Sérgio da Silva Santos

University of São Paulo (USP)

Date Written: November 13, 2020

Abstract

Background: The PHTALOX® mouthwash appears in this case series as a promising alternative for reducing the viral load of SARS-CoV-2 and for clinical improvement of infected patients.

Objectives: The aim of this study was to report a case series of mouthwash to reduce clinical symptoms in patients diagnosed with COVID-19.

Methods: Eight patients used 5ml of PHTALOX® mouthwash for gargling/rinsing during 1 minute/ five times a day during 14 days. Two measurement scales were applied for each patient in different periods to verify sore throat - VAS – Visual Analogic Scale for Pain and the clinical conditions - PS – Performance Status.

Results: All patients presented a significant reduction in clinical symptoms with PHTALOX® mouthwash for gargling/rinsing after few days of use, without hospitalization.

Conclusion: The PHTALOX® mouthwash protocol appears as a promising alternative for clinical improvement of COVID-19 infected patients. Daily use of this mouthwash rapidly reduced clinical symptoms such as sore throats, coughs and mouth ulcers. Clinical trials are necessary to confirm the effectiveness of PHTALOX® protocol against COVID-19.

Note: Funding: This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brazil (Finance Code 001).

Declaration of Interests: All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr. Vilhena reports personal fees from TRIALS Inc, during the conduct of the study; In addition, Dr. Vilhena has a patent classified pending. Dr. Araki reports grants from CNPq 401581/2016-0, grants from FAPESP 18/21489-1, during the conduct of the study; In addition, Dr. Araki has a patent null pending. Dr. DA SILVA SANTOS reports personal fees and other from null, during the conduct of the study; other from null, outside the submitted work. The other authors claim there are no conflicts of interest.

Ethics Approval Statement: Approved by ethics committee - 36493520.1.0000.5417

Keywords: mouthwash; sore throats; mouth ulcers; coronavirus infections

JEL Classification: I

Suggested Citation

Orcina, Bernardo da and Vieira Vilhena, Fabiano and Cardoso de Oliveira, Rodrigo and Marques da Costa Alves, Lucas and Araki, Koiti and Hiroshi Toma, Sérgio and Schutzer Ragghianti Zangrando, Mariana and da Silva Santos, Paulo Sérgio, PHTALOX® Mouthwash as An Option to Reduce Clinical Symptoms of COVID-19: Case Series (November 13, 2020). Available at SSRN: https://ssrn.com/abstract=3730292 or http://dx.doi.org/10.2139/ssrn.3730292

Bernardo da Orcina (Contact Author)

University of São Paulo (USP) ( email )

Av. Prof. Luciano Gualberto 380
Sao Paulo, 05508-010
Brazil

Fabiano Vieira Vilhena

TRIALS – Oral Health and Technologies ( email )

Brazil

Rodrigo Cardoso de Oliveira

University of São Paulo (USP) ( email )

Av. Prof. Luciano Gualberto 380
Sao Paulo, 05508-010
Brazil

Lucas Marques da Costa Alves

Hospital Estadual de Bauru ( email )

Brazil

Koiti Araki

University of São Paulo (USP) ( email )

Av. Prof. Luciano Gualberto 380
Sao Paulo, 05508-010
Brazil

Sérgio Hiroshi Toma

University of São Paulo (USP) ( email )

Av. Prof. Luciano Gualberto 380
Sao Paulo, 05508-010
Brazil

Mariana Schutzer Ragghianti Zangrando

University of São Paulo (USP) ( email )

Av. Prof. Luciano Gualberto 380
Sao Paulo, 05508-010
Brazil

Paulo Sérgio Da Silva Santos

University of São Paulo (USP) ( email )

Av. Prof. Luciano Gualberto 380
Sao Paulo, 05508-010
Brazil

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