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Comprehensive Analyses of Copy Number Variations In DNA Repair Genes Reveal the Role of Poly(ADP-Ribose) Polymerase in Longevity in Trees

53 Pages Posted: 19 Dec 2020 Publication Status: Review Complete

See all articles by Yuta Aoyagi Blue

Yuta Aoyagi Blue

Kyushu University - Graduate School of Systems Life Science

Junko Kusumi

Kyushu University - Department of Environmental Changes

Akiko Satake

Kyushu University - Department of Biology

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Abstract

Long-lived organisms are exposed to the risk of accumulating mutations due to DNA damage or replication errors. Previous studies in animals have revealed the positive relationship between the copy number of DNA repair genes and longevity. However, the role of DNA repair in the lifespan of plants remains poorly understood. Using the recent accumulation of the complete genome sequences of diverse plant species, we performed systematic comparative analyses of the copy number variations of DNA repair genes in 61 plant species with different lifespans. Among the 120 DNA repair gene families studied, the poly(ADP-ribose) polymerase (PARP) gene family, especially PARP1 and PARP2, was identified the gene revealing significant expansion in long-lived trees relative to annual and perennial herbs. PARPs catalyze poly(ADP-ribosyl)ation, a post-translational protein modification, and play pivotal roles in DNA repair and antipathogen defense. Our study suggests the conserved role of PARPs in longevity between animals and plants.

Suggested Citation

Aoyagi Blue, Yuta and Kusumi, Junko and Satake, Akiko, Comprehensive Analyses of Copy Number Variations In DNA Repair Genes Reveal the Role of Poly(ADP-Ribose) Polymerase in Longevity in Trees. Available at SSRN: https://ssrn.com/abstract=3751787 or http://dx.doi.org/10.2139/ssrn.3751787
This version of the paper has not been formally peer reviewed.

Yuta Aoyagi Blue (Contact Author)

Kyushu University - Graduate School of Systems Life Science ( email )

Japan

Junko Kusumi

Kyushu University - Department of Environmental Changes ( email )

6-19-1, Hakozaki, Higashiku
Fukuoka, 812-8581
Japan

Akiko Satake

Kyushu University - Department of Biology ( email )

Fukuoka, 819-0395
Japan

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