Comprehensive Analyses of Copy Number Variations In DNA Repair Genes Reveal the Role of Poly(ADP-Ribose) Polymerase in Longevity in Trees
53 Pages Posted: 19 Dec 2020 Publication Status: Review CompleteMore...
Long-lived organisms are exposed to the risk of accumulating mutations due to DNA damage or replication errors. Previous studies in animals have revealed the positive relationship between the copy number of DNA repair genes and longevity. However, the role of DNA repair in the lifespan of plants remains poorly understood. Using the recent accumulation of the complete genome sequences of diverse plant species, we performed systematic comparative analyses of the copy number variations of DNA repair genes in 61 plant species with different lifespans. Among the 120 DNA repair gene families studied, the poly(ADP-ribose) polymerase (PARP) gene family, especially PARP1 and PARP2, was identified the gene revealing significant expansion in long-lived trees relative to annual and perennial herbs. PARPs catalyze poly(ADP-ribosyl)ation, a post-translational protein modification, and play pivotal roles in DNA repair and antipathogen defense. Our study suggests the conserved role of PARPs in longevity between animals and plants.
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