Invisible Agents of COVID-19 Transmission? Common Sources, Characteristics, and Implications of Indoor Aerosols

44 Pages Posted: 29 Dec 2020

See all articles by Bo Chen

Bo Chen

Lanzhou University - College of Earth and Environmental Sciences; Xi'an Jiaotong University (XJTU) - Department of Environmental Science and Engineering, Xi'an Jiaotong University, Xi'an 710049, P.R. China

Puqi Jia

Lanzhou University - College of Earth and Environmental Sciences

Jie Han

Department of Environmental Science and Engineering, Xi'an Jiaotong University, Xi'an 710049, P.R. China

Date Written: December 21, 2020

Abstract

The positive association between outdoor atmospheric particulate matter and the morbidity and mortality of Coronavirus Disease 2019 (COVID-19) infections was concluded by recent studies. Since people spend most of their time indoor, aerosol particles generated by indoor activities have inherently closer links to human occupants and more direct implications on the airborne transmission of COVID-19. In light of this risk, we reviewed the characteristics of aerosol particles emitted from common indoor sources and how exposure to those particles affects human respiratory infections as well as the transport of airborne pathogens. Activities such as tobacco smoking, cooking, vacuum cleaning, laser printing, and burning candles, mosquito coils or incenses can generate large quantities of particles, mostly in the ultrafine range (< 100 nm). These tiny particles – each may have unique properties and aerodynamics depending on the sources and environmental conditions upon their release – could stay airborne and deposit in the deeper regions of human airways while being difficult to clear by the respiratory system. Adverse effects can be induced by inhaled aerosol particles via oxidative stress and inflammation. Early epidemiology evidence and animal studies showed the confounding effects of particle exposure in respiratory infections. Specifically, inhaled particles can impair human respiratory systems and immune functions and induce the upregulation of angiotensin-converting enzyme 2, causing vulnerability to COVID-19 infection. Moreover, co-production of inflammation mediators by COVID-19 infection and particle exposure magnifies the cytokine storm and aggravates symptoms in patients. We also discuss the possibility of indoor aerosol particles being virus carriers in the airborne transmission of COVID-19. Although many hypotheses were proposed in recent discussions, no rigorous evidence was provided to elucidate interactions between aerosol articles and virus-laden droplets or droplet nuclei, and studies are needed on how these interactions affect the persistence, transport, and lung deposition of COVID-19 and other airborne pathogens.

Note: Funding: This work was funded by the Young Talent Support Plan of Xi’an Jiaotong University.

Declaration of Interests: The authors declare that they have no conflict of interest in this work.

Keywords: Coronavirus, SARS-CoV-2, airborne, particulate, ultrafine, carrier

Suggested Citation

Chen, Bo and Jia, Puqi and Han, Jie, Invisible Agents of COVID-19 Transmission? Common Sources, Characteristics, and Implications of Indoor Aerosols (December 21, 2020). Available at SSRN: https://ssrn.com/abstract=3752556 or http://dx.doi.org/10.2139/ssrn.3752556

Bo Chen (Contact Author)

Lanzhou University - College of Earth and Environmental Sciences ( email )

Lanzhou, Gan Su 730000
China

Xi'an Jiaotong University (XJTU) - Department of Environmental Science and Engineering, Xi'an Jiaotong University, Xi'an 710049, P.R. China ( email )

26 West Xianning Road
Xi'an Jiaotong University (XJTU)
Xi'an, Shaanxi
China

Puqi Jia

Lanzhou University - College of Earth and Environmental Sciences ( email )

Lanzhou, Gan Su
China

Jie Han

Department of Environmental Science and Engineering, Xi'an Jiaotong University, Xi'an 710049, P.R. China ( email )

26 Xianning W Rd.
Xi'an Jiaotong University
Xi'an, Shaanxi 710049
China

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