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Association of Soy Intake with Cardiovascular Outcomes and All-Cause Mortality in Chinese Population: Results from a National Wide Prospective Cohort Study

23 Pages Posted: 26 Jan 2021

See all articles by Ting Xue

Ting Xue

Fujian Medical University - Center of Health Management

Junping Wen

Fujian Medical University - Department of Endocrinology

Qin Wan

The Affiliated Hospital of Luzhou Medical College

Guijun Qin

Zhengzhou University - Division of Endocrinology

Li Yan

Sun Yat-sen Memorial Hospital, Sun Yat-sen University

Guixia Wang

Jilin University (JLU) - Department of Endocrinology and Metabolism

Yingfen Qin

Guangxi Medical University - Department of Endocrine

Zuojie Luo

Guangxi Medical University - First Affiliated Hospital

Xulei Tang

Lanzhou University - Department of Endocrinology

Yanan Huo

Nanchang University - Jiangxi Medical School

Ruying Hu

Zhejiang Provincial Center for Disease Control and Prevention - Department of Non-Communicable Disease Control and Prevention

Zhen Ye

Zhejiang Provincial Center for Disease Control and Prevention

Lixin Shi

Guizhou Medical University (Guiyang Medical University) - First Affiliated Hospital

Zhengnan Gao

Dalian University - Dalian Municipal Central Hospital

Qing Su

Shanghai Jiao Tong University (SJTU) - Xinhua Hospital

Yiming Mu

Chinese PLA General Hospital - Department of Endocrinology

Jiajun Zhao

Shandong Provincial Hospital Affiliated to Shandong University

Lulu Chen

Huazhong University of Science and Technology - Tongji Medical College

Tianshu Zeng

Huazhong University of Science and Technology - Department of Endocrinology

Xuefeng Yu

Huazhong University of Science and Technology - Tongji Hospital

Qiang Li

Harbin Medical University - Second Affiliated Hospital

Feixia Shen

Wenzhou Medical University - First Affiliated Hospital

Li Chen

Qilu Hospital of Shandong University

Yinfei Zhang

Central Hospital of Shanghai Jiading District

Youmin Wang

Anhui Medical University - Department of Endocrinology

Huacong Deng

Chongqing Medical University - First Affiliated Hospital

Chao Liu

Jiangsu Province Hospital on Integration of Chinese and Western Medicine

Shengli Wu

Government of the People's Republic of China - Karamay Municipal People's Hospital

Tao Yang

Nanjing Medical University - Nanjing Medical Hospital

Mian Li

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Yu Xu

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Min Xu

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Tiange Wang

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Zhiyun Zhao

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Jieli Lu

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Yufang Bi

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Weiqing Wang

Shanghai Jiao Tong University (SJTU) - Shanghai Clinical Center for Endocrine and Metabolic Diseases

Gang Chen

Fujian Medical University - Department of Endocrinology; Fujian Academy of Medical Sciences - Fujian Provincial Key Laboratory of Medical Analysis

Guang Ning

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

More...

Abstract

Background: Whether soy products confer health benefits related to cardiovascular disease (CVD) and all-cause mortality remains unclear because of inconsistent evidence.

Methods: We conducted a population based, prospective cohort study among Chinese population. A total of 97 930 participants aged ≥ 40 years who had no cardiovascular disease at baseline were enrolled between 2011-2012. Habitual soy intake in the preceding 12 months was evaluated via a food frequency questionnaire. Follow up visit was conducted during 2014-2016 to assess incident CVD and all-cause mortality.

Results: During 350 604 person-years of follow-up, 2523 incident total CVD events and 1473 incident all-cause mortality, were documented. The Kaplan-Meier curves illustrated that participants with higher daily soy consumption had a decreased cumulative incidence of total CVD events (P=0.0445) and all-cause mortality (P=0.0053). After control for covariates, the hazard ratios (HRs) (95% CIs) for total CVD events across increasing soy intake were 1.02 (0.92-1.14), 0.96 (0.85-1.07), and 0.85 (0.74-0.98; P trend =0.0397), and the HRs (95%CIs) for all-cause mortality across increasing soy intake were 0.88 (0.77-1.02), 0.86 (0.74-1.00), and 0.83 (0.69-0.99; P trend =0.0083) among general population. For all-cause mortality, the adverse association seemed to be nonexistent among those with current smoking (P interaction =0.0523). No inverse association was observed between soy intake with non-fatal stroke, non-fatal myocardial infarction, hospitalized or treated heart failure, and CVD death among general population.

Conclusion: High soy intake seems to be associated with a lower risk of total CVD events and all-cause mortality among Chinese population.

Funding Statement: The research reported in this publication was supported by the Ministry of Science and Technology of the People’s Republic of China (award nos. 2016YFC1305600, 2016YFC1305202, 2016YFC1304904, 2017YFC1310700, 2018YFC1311705, 2018YFC1311800), the Chinese Medical Association Foundation and Chinese Endocrine Society (12020240314), and the National Key New Drug Creation and Manufacturing Program of Ministry of Science and Technology (2012ZX09303006-001).

Declaration of Interests: None.

Ethics Approval Statement: The study was approved by the Medical Ethics Committee of Ruijin Hospital, Shanghai Jiaotong University. All participants signed the written informed consent.

Keywords: soy, cardiovascular disease, all-cause mortality

Suggested Citation

Xue, Ting and Wen, Junping and Wan, Qin and Qin, Guijun and Yan, Li and Wang, Guixia and Qin, Yingfen and Luo, Zuojie and Tang, Xulei and Huo, Yanan and Hu, Ruying and Ye, Zhen and Shi, Lixin and Gao, Zhengnan and Su, Qing and Mu, Yiming and Zhao, Jiajun and Chen, Lulu and Zeng, Tianshu and Yu, Xuefeng and Li, Qiang and Shen, Feixia and Chen, Li and Zhang, Yinfei and Wang, Youmin and Deng, Huacong and Liu, Chao and Wu, Shengli and Yang, Tao and Li, Mian and Xu, Yu and Xu, Min and Wang, Tiange and Zhao, Zhiyun and Lu, Jieli and Bi, Yufang and Wang, Weiqing and Chen, Gang and Ning, Guang, Association of Soy Intake with Cardiovascular Outcomes and All-Cause Mortality in Chinese Population: Results from a National Wide Prospective Cohort Study. Available at SSRN: https://ssrn.com/abstract=3756858 or http://dx.doi.org/10.2139/ssrn.3756858

Ting Xue

Fujian Medical University - Center of Health Management

Fuzhou
China

Junping Wen

Fujian Medical University - Department of Endocrinology ( email )

China

Qin Wan

The Affiliated Hospital of Luzhou Medical College

Guijun Qin

Zhengzhou University - Division of Endocrinology ( email )

Li Yan

Sun Yat-sen Memorial Hospital, Sun Yat-sen University

Guixia Wang

Jilin University (JLU) - Department of Endocrinology and Metabolism ( email )

China

Yingfen Qin

Guangxi Medical University - Department of Endocrine

Nanning, Guangxi 530021
China

Zuojie Luo

Guangxi Medical University - First Affiliated Hospital

Guangxi, 530021
China

Xulei Tang

Lanzhou University - Department of Endocrinology

Lanzhou, Gansu 730000
China

Yanan Huo

Nanchang University - Jiangxi Medical School

Nanchang, 330000
China

Ruying Hu

Zhejiang Provincial Center for Disease Control and Prevention - Department of Non-Communicable Disease Control and Prevention ( email )

Hangzhou
China

Zhen Ye

Zhejiang Provincial Center for Disease Control and Prevention

Binjiang
Hangzhou, Zhejiang 310051
China

Lixin Shi

Guizhou Medical University (Guiyang Medical University) - First Affiliated Hospital

Guiyang, Guizhou 550004
China

Zhengnan Gao

Dalian University - Dalian Municipal Central Hospital

Dalian
China

Qing Su

Shanghai Jiao Tong University (SJTU) - Xinhua Hospital

Shanghai
China

Yiming Mu

Chinese PLA General Hospital - Department of Endocrinology

Beijing, 100853
China

Jiajun Zhao

Shandong Provincial Hospital Affiliated to Shandong University

Lulu Chen

Huazhong University of Science and Technology - Tongji Medical College ( email )

Tianshu Zeng

Huazhong University of Science and Technology - Department of Endocrinology

Wuhan, Hubei 430022
China

Xuefeng Yu

Huazhong University of Science and Technology - Tongji Hospital

1239 Siping Road
Shanghai, 200092
China

Qiang Li

Harbin Medical University - Second Affiliated Hospital

Harbin
China

Feixia Shen

Wenzhou Medical University - First Affiliated Hospital

Wenzhou, Zhejiang Province
China

Li Chen

Qilu Hospital of Shandong University

Yinfei Zhang

Central Hospital of Shanghai Jiading District

Shanghai
China

Youmin Wang

Anhui Medical University - Department of Endocrinology

Hefei, Anhui 230000
China

Huacong Deng

Chongqing Medical University - First Affiliated Hospital

Chongqing
China

Chao Liu

Jiangsu Province Hospital on Integration of Chinese and Western Medicine

Nanjing
China

Shengli Wu

Government of the People's Republic of China - Karamay Municipal People's Hospital

Xinjiang
China

Tao Yang

Nanjing Medical University - Nanjing Medical Hospital

Nanjing
China

Mian Li

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Shanghai
China

Yu Xu

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Shanghai
China

Min Xu

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

Tiange Wang

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Shanghai
China

Zhiyun Zhao

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Shanghai
China

Jieli Lu

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Shanghai
China

Yufang Bi

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Shanghai
China

Weiqing Wang

Shanghai Jiao Tong University (SJTU) - Shanghai Clinical Center for Endocrine and Metabolic Diseases ( email )

Shanghai
China

Gang Chen (Contact Author)

Fujian Medical University - Department of Endocrinology ( email )

China
+86-1350933707 (Phone)

Fujian Academy of Medical Sciences - Fujian Provincial Key Laboratory of Medical Analysis

China

Guang Ning

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

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