Acyclovir as a Potential Adjuvant Therapy in COVID-19 Treatment Regimens

Heidary F, Madani S, Gharebaghi R, Asadi-amoli F. Acyclovir as a Potential Adjuvant Therapy in COVID-19 Treatment Regimens. Pharm Sci. doi: 10.34172/PS.2021.38, Published on: 2021 Jul 08, https://ps.tbzmed.ac.ir/Inpress/ps-34330

19 Pages Posted: 21 Jan 2021 Last revised: 2 Aug 2021

See all articles by A/Prof. Fatemeh Heidary

A/Prof. Fatemeh Heidary

International Virtual Ophthalmic Research Center

Sedigheh Madani

Tehran University of Medical Sciences - Endocrinology and Metabolism Clinical Sciences Institute

Reza Gharebaghi

Shahed University

Fahimeh Asadi-Amoli

Tehran University of Medical Sciences

Date Written: January 17, 2021

Abstract

Introduction: There are successful reports of the concomitant management of herpes infection and coronavirus disease 2019 (COVID-19), using both acyclovir (ACV) and COVID-19 treatment regimens. Furthermore, ACV has been proposed to effectively treat COVID-19, through various mechanisms, such as inhibition of viral proteases, multiple viral gene expressions, and RNA-dependent RNA polymerase (RdRP). Therefore, this study aimed to review the reported cases of patients with concomitant herpes infection and COVID-19, receiving concurrent antiviral drugs for herpetic lesions.

Methods: A search was done to find the relevant articles, published between December 2019 and December 2020, with no language limitations, in the PubMed database, using the Medical Subject Headings (MeSH) terms related to herpes simplex virus or herpes zoster (namely, shingles) combined with COVID-19. Accordingly, the reports of the concomitant herpes infection and COVID-19, receiving concurrent antiviral drugs for herpetic lesions were included.

Results: Out of 90 articles, 11 records reporting the cases of herpes infection and concurrent laboratory-confirmed COVID-19, receiving antiherpetic therapies, were reviewed. There were 28 patients (age range of 7-82 years) with laboratory-confirmed COVID-19, concomitant with reactivation of herpes infection, receiving antiviral drugs alongside candidate COVID-19 treatment regimens, but no mortality. The mean (standard deviation [SD] range) age of these 28 patients during treatment was 56.4 (18.6 [7-82]) years, and the majority were male (n=18, 64.3%). A total number of 20 patients had also received ACV and eight cases had been administered with other two antiviral compounds, including seven cases with valacyclovir, and one case with famciclovir, with no mortality.

Conclusion: The potential use of ACV, as an add-on therapy, along with candidate COVID-19 treatment regimens was proposed in this study. However, further clinical trials are recommended to test this hypothetical adjuvant therapy.

Note: Funding: None.

Declaration of Interests: None.

Keywords: COVID-19, SARS-CoV-2, 2019-nCoV, severe acute respiratory syndrome coronavirus 2, coronavirus disease 2019; acyclovir sodium, herpes simplex virus infection, zona, zoster, shingles, reverse transcriptase PCR

Suggested Citation

Heidary, Fatemeh and Madani, Sedigheh and Gharebaghi, Reza and Asadi-Amoli, Fahimeh, Acyclovir as a Potential Adjuvant Therapy in COVID-19 Treatment Regimens (January 17, 2021). Heidary F, Madani S, Gharebaghi R, Asadi-amoli F. Acyclovir as a Potential Adjuvant Therapy in COVID-19 Treatment Regimens. Pharm Sci. doi: 10.34172/PS.2021.38, Published on: 2021 Jul 08, https://ps.tbzmed.ac.ir/Inpress/ps-34330 , Available at SSRN: https://ssrn.com/abstract=3767875 or http://dx.doi.org/10.2139/ssrn.3767875

Fatemeh Heidary (Contact Author)

International Virtual Ophthalmic Research Center ( email )

Suite No 4000, 5900 Balcones Drive, STE 100, Austi
Austin, TX 78731
United States

HOME PAGE: http://www.drfatemeh.com

Sedigheh Madani

Tehran University of Medical Sciences - Endocrinology and Metabolism Clinical Sciences Institute ( email )

United States

Reza Gharebaghi

Shahed University ( email )

Persian Gulf Freeway
Tehran
Iran

Fahimeh Asadi-Amoli

Tehran University of Medical Sciences ( email )

Number 21, Dameshg St.
Vali-e Asr Ave.
Tehran, 14195
Iran

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