Complete, Durable Remission of Advanced Hepatocellular Carcinoma Under Treatment with Viscum Album Extracts – A Case Report

21 Pages Posted: 17 Feb 2021

See all articles by Maurice Orange

Maurice Orange

Klinik Arlesheim - Oncological Day Clinic

Nicoletta Poidimani

Casa Andrea Cristoforo

Andrea Crosignani

Ospedale San Paolo

Paul G. Werthmann Dr. Med

Institute for Applied Epistemology and Medical Methodology – University of Witten-Herdecke; University of Freiburg (Germany) - Center for Complementary Medicine; University Hospital Ulm

Corrado Bertotto

Kantonsspital St Gallen

Date Written: January 29, 2021

Abstract

Background: Hepatocellular carcinoma (HCC) is the 3rd leading cause of cancer deaths worldwide. Early stage disease is treated with surgery or transplantation with curative intent, but most patients present with advanced HCC, which carries a poor prognosis. Even with palliative systemic treatment – typically a kinase inhibitor – advanced HCC carries a life expectancy of a year or less. Viscum album extracts (VAE) are used by cancer patients as an adjunct for cancer treatment or palliation.

Case Summary: A 51-year old female with a 30-year history of hepatitis C virus infection, presented with relapsing multifocal hepatocellular cancer, stage C in the Barcelona Clinic Liver Cancer staging system, following primary resection of a single lesion 3 months earlier. She declined palliative treatment and commenced intravenous application of VAE. The intravenous VAE treatment was given in conjunction with intravenous hepato-protective L-ornithine L-aspartate (LOLA). Under this treatment she experienced a significant improvement of life-quality and performance status. Three months later a significant regression was noted on computerised tomography scanning and her tumour marker (α-foetoprotein) was in normal reference range, where it remains to date. Further imaging 11 months later confirmed a complete regression. The subcutaneous and intravenous VAE, as well as LOLA treatment continues to date. The regression is sustained for 31/2 years at publication, confirmed by regular imaging and serology. The patient is experiencing an excellent, unrestricted quality of life. The patient had no other cancer-directed therapy and no treatment of her hepatitis C infection.

Conclusion: Complete regression of advanced HCC is rare, spontaneous regression is even rarer. Disease responses to VAE treatment of HCC have been reported before. However, this is the first documented case with a complete and durable regression of an HCC under treatment with VAE. Further studies should evaluate benefits of VAE treatment in HCC, especially when administered in forms as reported here.

Keywords: Hepatocellular carcinoma, Viscum album, Complete remission, Case report

Suggested Citation

Orange, Maurice and Poidimani, Nicoletta and Crosignani, Andrea and Werthmann, Paul G. and Bertotto, Corrado, Complete, Durable Remission of Advanced Hepatocellular Carcinoma Under Treatment with Viscum Album Extracts – A Case Report (January 29, 2021). Available at SSRN: https://ssrn.com/abstract=3775671 or http://dx.doi.org/10.2139/ssrn.3775671

Maurice Orange

Klinik Arlesheim - Oncological Day Clinic ( email )

Switzerland

Nicoletta Poidimani

Casa Andrea Cristoforo ( email )

Ascona, 6612
Switzerland

Andrea Crosignani

Ospedale San Paolo ( email )

Milano
Italy

Paul G. Werthmann (Contact Author)

Institute for Applied Epistemology and Medical Methodology – University of Witten-Herdecke ( email )

Zechenweg 6
Freiburg, 79111, DE
Germany

HOME PAGE: http://www.ifaemm.de

University of Freiburg (Germany) - Center for Complementary Medicine ( email )

Breisacher Str. 115B
Freiburg, 79110

University Hospital Ulm ( email )

Albert-Einstein-Allee 23
Ulm, 89081
Germany

Corrado Bertotto

Kantonsspital St Gallen ( email )

St Gallen, 9007
Switzerland

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