SARS-CoV-2 Seroprevalence and Associated Factors in Manaus, Brazil: Baseline Results from the DETECTCoV-19 Cohort Study

57 Pages Posted: 4 Mar 2021 Last revised: 9 Mar 2021

See all articles by Pritesh Lalwani

Pritesh Lalwani

Instituto Leônidas e Maria Deane (ILMD), Fiocruz Amazônia, Manaus, Amazonas, Brazil

Bárbara Batista Salgado

Instituto Leônidas & Maria Deane (Fiocruz)

Ivanildo Vieira Pereira Filho

Federal University of Amazonas - UFAM

Danielle Severino Sena da Silva

Instituto Leônidas & Maria Deane (Fiocruz)

Thiago Barros do Nascimento de Morais

Instituto Leônidas & Maria Deane (Fiocruz)

Maele Ferreira Jordão

Instituto Leônidas & Maria Deane (Fiocruz)

Aguyda Rayany Cavalcante Barbosa

Instituto Leônidas & Maria Deane (Fiocruz)

Isabelle Bezerra Cordeiro

Federal University of Amazonas - UFAM

Júlio Nino de Souza Neto

Federal University of Amazonas - UFAM

Enedina Nogueira de Assunção

Federal University of Amazonas - UFAM

Rafaella Oliveira dos Santos

Instituto Leônidas & Maria Deane (Fiocruz)

Nani Oliveira Carvalho

Instituto Leônidas & Maria Deane (Fiocruz)

Wlademir Braga Salgado Sobrinho

Instituto Leônidas & Maria Deane (Fiocruz)

Cristiano Fernandes da Costa

Fundação de Vigilância em Saúde do Amazonas

Pedro Elias de Souza

Federal University of Amazonas - UFAM

Bernardino Claudio de Albuquerque

Federal University of Amazonas - UFAM

Christian Ganoza

Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia

Roger V. Araujo-Castillo

Universidad Peruana de Ciencias Aplicadas

Spartaco Astofi Filho

Federal University of Amazonas - UFAM

Jaila Dias Borges Lalwani

Faculdade de Ciências Farmacêuticas (FCF), Universidade Federal do Amazonas (UFAM)

DETECTCoV-19 Study Team

affiliation not provided to SSRN

Date Written: February 26, 2021

Abstract

Background: Manaus located in the Brazilian rainforest has twice experienced a health system collapse due to the SARS-CoV-2 pandemic. However, little is known about which groups among the general population have been more affected.

Methods: A convenience sampling strategy via online advertising recruited 3046 adults. Sociodemographic characteristics, COVID-19-related symptoms, COVID-19 testing, self-medication and prescribed medications were recorded. Serum anti-SARS-CoV-2 nucleocapsid IgG antibodies were measured with an ELISA. Prevalence ratios (PR) were obtained using cluster-corrected and adjusted Poisson’s regression models.

Results: A crude positivity rate among asymptomatic and symptomatic individuals, was estimated at 29.10%, with a maximum seroprevalence of 41.53% corrected by test characteristics and an antibody decay rate of 27%. Regression models demonstrated a strong association towards marginalized low-income and vulnerable residents with limited health access. Presence of a COVID-19 case (PR 1.39, 1.24-1.57) or death (PR 2.14, 1.74-2.62) in a household increased greatly the risk of other household members acquiring infection. SARS-CoV-2 seroprevalence was higher among those who self-medicated to prevent infection (PR 1.36, 1.27-1.46).

Conclusions: A disproportionate social and economic disparity was observed among the study participants. The syndemic nature of COVID-19 in the Amazon region needs differential policies and urgent solutions to control the ongoing pandemic.

Note: Funding Statement: Ministry of Education (MEC), Brazil.

Declaration of Interests: The authors declare no conflict of interest.

Ethics Approval Statement: The research ethics committee of Federal University of Amazonas (UFAM) approved this study (CAAE:34906920.4.0000.5020) in accordance with Brazilian law

Keywords: Epidemiology, SARS-CoV-2, Manaus, Amazon, Brazil, Risk Factors, Seroprevalence, COVID-19

Suggested Citation

Lalwani, Pritesh and Salgado, Bárbara Batista and Pereira Filho, Ivanildo Vieira and Silva, Danielle Severino Sena da and Morais, Thiago Barros do Nascimento de and Jordão, Maele Ferreira and Barbosa, Aguyda Rayany Cavalcante and Cordeiro, Isabelle Bezerra and Neto, Júlio Nino de Souza and Assunção, Enedina Nogueira de and Santos, Rafaella Oliveira dos and Carvalho, Nani Oliveira and Sobrinho, Wlademir Braga Salgado and Costa, Cristiano Fernandes da and Souza, Pedro Elias de and Albuquerque, Bernardino Claudio de and Ganoza, Christian and Araujo-Castillo, Roger V. and Astofi Filho, Spartaco and Lalwani, Jaila Dias Borges and Study Team, DETECTCoV-19, SARS-CoV-2 Seroprevalence and Associated Factors in Manaus, Brazil: Baseline Results from the DETECTCoV-19 Cohort Study (February 26, 2021). Available at SSRN: https://ssrn.com/abstract=3795816 or http://dx.doi.org/10.2139/ssrn.3795816

Pritesh Lalwani (Contact Author)

Instituto Leônidas e Maria Deane (ILMD), Fiocruz Amazônia, Manaus, Amazonas, Brazil ( email )

Manaus
Brazil

Bárbara Batista Salgado

Instituto Leônidas & Maria Deane (Fiocruz) ( email )

Manaus
Brazil

Ivanildo Vieira Pereira Filho

Federal University of Amazonas - UFAM ( email )

Avenida Rodrigo Otávio, 3000
Manaus, 69000000
Brazil

Danielle Severino Sena da Silva

Instituto Leônidas & Maria Deane (Fiocruz) ( email )

Manaus
Brazil

Thiago Barros do Nascimento de Morais

Instituto Leônidas & Maria Deane (Fiocruz) ( email )

Manaus
Brazil

Maele Ferreira Jordão

Instituto Leônidas & Maria Deane (Fiocruz) ( email )

Manaus
Brazil

Aguyda Rayany Cavalcante Barbosa

Instituto Leônidas & Maria Deane (Fiocruz) ( email )

Manaus
Brazil

Isabelle Bezerra Cordeiro

Federal University of Amazonas - UFAM ( email )

Avenida Rodrigo Otávio, 3000
Manaus, 69000000
Brazil

Júlio Nino de Souza Neto

Federal University of Amazonas - UFAM

Avenida Rodrigo Otávio, 3000
Manaus, 69000000
Brazil

Enedina Nogueira de Assunção

Federal University of Amazonas - UFAM ( email )

Avenida Rodrigo Otávio, 3000
Manaus, 69000000
Brazil

Rafaella Oliveira dos Santos

Instituto Leônidas & Maria Deane (Fiocruz) ( email )

Manaus
Brazil

Nani Oliveira Carvalho

Instituto Leônidas & Maria Deane (Fiocruz) ( email )

Manaus
Brazil

Wlademir Braga Salgado Sobrinho

Instituto Leônidas & Maria Deane (Fiocruz) ( email )

Manaus
Brazil

Cristiano Fernandes da Costa

Fundação de Vigilância em Saúde do Amazonas ( email )

Manaus
Brazil

Pedro Elias de Souza

Federal University of Amazonas - UFAM ( email )

Avenida Rodrigo Otávio, 3000
Manaus, 69000000
Brazil

Bernardino Claudio de Albuquerque

Federal University of Amazonas - UFAM

Avenida Rodrigo Otávio, 3000
Manaus, 69000000
Brazil

Christian Ganoza

Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia ( email )

Av. Honorio Delgado 430
Lima, SMP
Peru

Roger V. Araujo-Castillo

Universidad Peruana de Ciencias Aplicadas ( email )

Prolongación Primavera 2390, Monterrico
Lima, Lima
Peru

Spartaco Astofi Filho

Federal University of Amazonas - UFAM ( email )

Avenida Rodrigo Otávio, 3000
Manaus, 69000000
Brazil

Jaila Dias Borges Lalwani

Faculdade de Ciências Farmacêuticas (FCF), Universidade Federal do Amazonas (UFAM) ( email )

Avenida Rodrigo Otávio, 3000
Manaus, 69000000
Brazil

DETECTCoV-19 Study Team

affiliation not provided to SSRN

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