Randomized COVID-19 Vaccination Rollout

Abstract

Vaccines will be vital to control the Coronavirus disease 2019 (COVID-19) pandemic, but the pressure to quickly move from research to implementation raises concerns about benefits and harms, vaccine acceptance and fair access. Here we present a strategy for the COVID-19 vaccination rollout which can be rapidly embedded and would offer direct real-world evidence of vaccines on a large scale to generate otherwise unobtainable knowledge on the safety and perhaps efficacy of COVID-19 vaccines.

Note: Funding Statement: None.

Declaration of Interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf. There are no relationships or activities that could appear to have influenced the submitted work.

Keywords: COVID-19, vaccines, randomization, study design