An Intelligent Responsive Macrophage Cell Membrane Camouflaged Mesoporous Silicon Nanorods Drug Delivery System for Precise Targeted Therapy Of Tumor

47 Pages Posted: 29 Mar 2021

See all articles by Minghua Li

Minghua Li

Tongji University - Department of Radiology

Xiaolong Gao

Shanghai University

Chao Lin

Tongji University - Institute for Translational Medicine

Maoquan Chu

Tongji University

Weizhong Yuan

Tongji University - Institute of Nano and Biopolymeric Materials

Aijun Shen

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Radiology

Jing Luo

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Radiology

Qiongqiong Ji

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Radiology

Jiaqi Wu

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Radiology

Peijun Wang

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Radiology

Abstract

Macrophage cell membrane camouflaged nanocarriers can effectively reduce immune clearance and  target the tumor actively. In this study, a macrophage cell membrane camouflaged mesoporous silica nanorods (MSNRs) based anti-tumor drugcarrier equipped with a cationic polymer layer is developed. As a drugcarrier, MSNRs are loaded with the thermosensitive phase change material L-menthol (LM), the chemotherapy drug doxorubicin (DOX) and the  fluorescent molecule indocyanine green (ICG). The rod-like shape of MSNRs is shown to improve the penetration of the drugcarrier to the tumor. In the weakly acidic tumor microenvironment, the cationic polymer presents a proton sponge effect to trigger macrophage cell membrane coating detachment, thus promoting tumor cell uptake. Following nanocarrier uptake, ICG is heated by near-infrared (NIR) irradiation to make LM undergo a phase transition to release DOX and generate a synergistic effect of thermochemotherapy which kills tumor cells and inhibits tumor growth together with reactive oxygen species (ROS) produced by ICG. Overall, this nanohybrid drug delivery system demonstrats an intelligent cascade response effect and achieves tissue–cell specific targeting and improves drug release accuracy, thus proving to be an effective cancer therapy.

Suggested Citation

Li, Minghua and Gao, Xiaolong and Lin, Chao and Chu, Maoquan and Yuan, Weizhong and Shen, Aijun and Luo, Jing and Ji, Qiongqiong and Wu, Jiaqi and Wang, Peijun, An Intelligent Responsive Macrophage Cell Membrane Camouflaged Mesoporous Silicon Nanorods Drug Delivery System for Precise Targeted Therapy Of Tumor. Available at SSRN: https://ssrn.com/abstract=3814586 or http://dx.doi.org/10.2139/ssrn.3814586

Minghua Li

Tongji University - Department of Radiology ( email )

Shanghai
China

Xiaolong Gao

Shanghai University ( email )

No.88 Yongshun Road
No.99 Shangda Road
Shanghai 200444, Shanghai 200444
China
+86-66861212 (Phone)
+86-66861212 (Fax)

Chao Lin

Tongji University - Institute for Translational Medicine

Shanghai
China

Maoquan Chu

Tongji University

Shanghai
China

Weizhong Yuan

Tongji University - Institute of Nano and Biopolymeric Materials ( email )

Shanghai
China

Aijun Shen

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Radiology ( email )

No.1095 Jiefang Avenue
Wuhan, 430030
China

Jing Luo

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Radiology

No.1095 Jiefang Avenue
Wuhan, 430030
China

Qiongqiong Ji

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Radiology ( email )

No.1095 Jiefang Avenue
Wuhan, 430030
China

Jiaqi Wu

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Radiology

No.1095 Jiefang Avenue
Wuhan, 430030
China

Peijun Wang (Contact Author)

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Radiology ( email )

No.1095 Jiefang Avenue
Wuhan, 430030
China

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