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Cyst Cells Control Germ Cell Progenitor Numbers Via the Phagocytic Receptor Draper

30 Pages Posted: 15 Apr 2021 Publication Status: Under Review

See all articles by Maayan Zohar-Fux

Maayan Zohar-Fux

University of Haifa - Department of Human Biology

Aya Ben-Hamo-Arad

University of Haifa - Department of Human Biology

Tal Arad

University of Haifa - Department of Human Biology

Marina Volin

University of Haifa - Department of Human Biology

Lilach Porat-Kuperstein

University of Haifa - Department of Human Biology

Estee Kurant

University of Haifa - Department of Human Biology

Hila Toledano

University of Haifa - Department of Human Biology

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Abstract

Rapid and constant proliferation generates a pool of germ cell (GC) progenitors for spermatogenesis. In an evolutionarily conserved process, almost a quarter of the nascent progenitors are removed by GC death, although the mechanisms that provoke this phenomenon remain largely unknown. Here, we report that in the Drosophila testis, support cyst cells, the functional orthologues of mammalian Sertoli cells, eliminate live GC progenitors. Cyst cells rely on the phagocytic receptor Draper (Drpr) and dJNK signaling to engulf live GCs and then clear the resulting debris. We show that unlike the fine-tuned phagocytosis of dead cells, only pro-phagocytic Drpr isoforms regulate the removal of live cells. We further show that Drpr levels decline with age, resulting in reduced elimination of progenitors and prolonged spermatogenesis. Since GC death is dictated by neighboring cyst cells, inhibition of paracrine signaling between the two cell types may provide a means for prolonging fertility.

Suggested Citation

Zohar-Fux, Maayan and Ben-Hamo-Arad, Aya and Arad, Tal and Volin, Marina and Porat-Kuperstein, Lilach and Kurant, Estee and Toledano, Hila, Cyst Cells Control Germ Cell Progenitor Numbers Via the Phagocytic Receptor Draper. Available at SSRN: https://ssrn.com/abstract=3827405 or http://dx.doi.org/10.2139/ssrn.3827405
This version of the paper has not been formally peer reviewed.

Maayan Zohar-Fux

University of Haifa - Department of Human Biology

Mount Carmel
Haifa, 31905
Israel

Aya Ben-Hamo-Arad

University of Haifa - Department of Human Biology

Mount Carmel
Haifa, 31905
Israel

Tal Arad

University of Haifa - Department of Human Biology

Israel

Marina Volin

University of Haifa - Department of Human Biology

Israel

Lilach Porat-Kuperstein

University of Haifa - Department of Human Biology

Mount Carmel
Haifa, 31905
Israel

Estee Kurant

University of Haifa - Department of Human Biology

Mount Carmel
Haifa, 31905
Israel

Hila Toledano (Contact Author)

University of Haifa - Department of Human Biology ( email )

Israel

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