lancet-header

Preprints with The Lancet is a collaboration between The Lancet Group of journals and SSRN to facilitate the open sharing of preprints for early engagement, community comment, and collaboration. Preprints available here are not Lancet publications or necessarily under review with a Lancet journal. These preprints are early-stage research papers that have not been peer-reviewed. The usual SSRN checks and a Lancet-specific check for appropriateness and transparency have been applied. The findings should not be used for clinical or public health decision-making or presented without highlighting these facts. For more information, please see the FAQs.

Benefit-Cost Analysis of Introducing Double Fortified Salt for Control of Iron Deficiency Anemia in India

41 Pages Posted: 26 Apr 2021

See all articles by Sanchit Makkar

Sanchit Makkar

St. John’s Research Institute - Division of Nutrition

Sumedha Minocha

St. John’s Research Institute - Division of Nutrition

Kishor Govinda Bhat

St. John’s Research Institute - Division of Nutrition

Anjaly Teresa John

St. John’s Research Institute - Division of Nutrition

Sumathi Swaminathan

St. John’s Research Institute - Division of Nutrition

Tinku Thomas

St John’s Medical College - Department of Biostatistics

M.G. Venkatesh Mannar

University of Toronto - Department of Chemical Engineering and Applied Chemistry

Anura V. Kurpad

St John’s Medical College - Department of Physiology

More...

Abstract

Background: The alleviation of iron deficiency through iron supplementation has not effectively reduced anemia in India, mainly due to low compliance. Food fortification with iron is now considered a viable alternative, and the provision of double fortified salt (DFS, with iron and iodine) has been mandated in public health programs. Still, there is limited evidence on its benefit-cost ratio.

Methods: The economic benefit, in terms of wages earned, of introducing DFS in India was derived using a series of mathematical, statistical and econometric models using data from national surveys capturing earnings and dietary iron intake of the population. Anemia status was predicted from data on dietary intake, sanitation and for women, menstrual losses. The association of iron deficiency anemia (IDA) and wages was estimated using a Heckman Selection model, followed by estimation of the benefit of DFS through increased wages attributed to anemia reduction compared to its cost.

Findings: Men and women with IDA had lower wages (by 25·9%, 95%CI: [11·3,38·1] and by 3·9%, 95%CI: [0·0,7·7] respectively) compared to those without IDA. Additional iron intake through DFS was predicted to reduce the prevalence of IDA (from 10·6% to 0·7% in men; 23·8% to 20·9% in women). The economic benefit-to-cost ratio of introducing DFS at a national level was estimated at 4·2:1.InterpretationIron fortification delivered through DFS under a universal program, can improve wages and be sufficiently cost-effective for its implementation at scale in India.

Funding: International Development Research Centre [grant number-108123].

Declaration of Interest: We declare no competing interests.

Ethical Approval: For the primary study from Jharkhand, institutional ethics approval was obtained from both St. John’s Medical College, Bangalore, Karnataka, India and Rajendra Institute of Medical Sciences (RIMS), Ranchi, Jharkhand, India. Informed consent was obtained from all the participants.

Suggested Citation

Makkar, Sanchit and Minocha, Sumedha and Bhat, Kishor Govinda and John, Anjaly Teresa and Swaminathan, Sumathi and Thomas, Tinku and Mannar, M.G. Venkatesh and Kurpad, Anura V., Benefit-Cost Analysis of Introducing Double Fortified Salt for Control of Iron Deficiency Anemia in India. Available at SSRN: https://ssrn.com/abstract=3834271 or http://dx.doi.org/10.2139/ssrn.3834271

Sanchit Makkar

St. John’s Research Institute - Division of Nutrition ( email )

Bengaluru
India

Sumedha Minocha

St. John’s Research Institute - Division of Nutrition

Bengaluru
India

Kishor Govinda Bhat

St. John’s Research Institute - Division of Nutrition ( email )

Bengaluru
India

Anjaly Teresa John

St. John’s Research Institute - Division of Nutrition ( email )

Bengaluru
India

Sumathi Swaminathan

St. John’s Research Institute - Division of Nutrition ( email )

Bengaluru
India

Tinku Thomas

St John’s Medical College - Department of Biostatistics ( email )

M.G. Venkatesh Mannar

University of Toronto - Department of Chemical Engineering and Applied Chemistry ( email )

105 St George Street
Toronto, Ontario M5S 3G8
Canada

Anura V. Kurpad (Contact Author)

St John’s Medical College - Department of Physiology ( email )