Magnetic Resonance Imaging and Rna Interference of Tumor with Reducible Poly(Urethane-Amine) Nanocomposite System

43 Pages Posted: 12 May 2021

See all articles by Xiaolong Gao

Xiaolong Gao

Shanghai University

Junjun Tang

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Radiology

Minghua Li

Tongji University - Department of Radiology

Chao Lin

Tongji University - Institute for Translational Medicine

Maoquan Chu

Tongji University

Peijun Wang

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Radiology

Abstract

Gadolinium-based small-molecule contrast agents are commonly utilized in clinics. However, these agents have a short retention time in vivo and possess a certain level of cytotoxicity. The reducible polymer poly(urethane-amine) can increase the relaxation rate and blood circulation time of small-molecule gadolinium chelates. Moreover, the polymer can be used as a gene carrier to bind small interfering RNA (siRNA). We synthesized an active targeting integrated diagnosis and treatment nanocomposite system with reducible poly(urethane-amine) as the carrier. This system incorporated functional units such as MRI contrast agent Gd-diethylenetriamine pentacetate (Gd-DTPA) and siRNA-vascular endothelial growth factor (siRNA-VEGF), and folic acid (FA) modified onto the surface of the polymer directed it to actively target tumor cells, thus improving the imaging effect of MRI. Meanwhlie, siRNA-VEGF carried by the system could reduce the expression of VEGF in tumor cells and inhibited tumor growth. The system showed good biocompatibility and was an integrated system of tumor diagnosis and treatment.

Suggested Citation

Gao, Xiaolong and Tang, Junjun and Li, Minghua and Lin, Chao and Chu, Maoquan and Wang, Peijun, Magnetic Resonance Imaging and Rna Interference of Tumor with Reducible Poly(Urethane-Amine) Nanocomposite System. Available at SSRN: https://ssrn.com/abstract=3844708 or http://dx.doi.org/10.2139/ssrn.3844708

Xiaolong Gao

Shanghai University ( email )

No.88 Yongshun Road
No.99 Shangda Road
Shanghai 200444, Shanghai 200444
China
+86-66861212 (Phone)
+86-66861212 (Fax)

Junjun Tang

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Radiology ( email )

No.1095 Jiefang Avenue
Wuhan, 430030
China

Minghua Li

Tongji University - Department of Radiology ( email )

Shanghai
China

Chao Lin

Tongji University - Institute for Translational Medicine

Shanghai
China

Maoquan Chu

Tongji University

Shanghai
China

Peijun Wang (Contact Author)

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Radiology ( email )

No.1095 Jiefang Avenue
Wuhan, 430030
China

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