Real-Time Potentiometric Sensor; an Innovative Tool for Monitoring Hydrolysis of Chemo/Bio-Degradable Drugs in Pharmaceutical Sciences

J Pharm Biomed Anal. 2018 May 30;154:166-173

Posted: 16 Jun 2021

See all articles by Ahmed Ma’mun

Ahmed Ma’mun

Heliopolis University - Faculty of Pharmacy

Mohamed K. Abd Elrahman

Cairo University

Mohamed Abd El-Kawy

Future University, Egypt

Date Written: May 6, 2018

Abstract

In recent years, the whole field of ion-selective electrodes (ISEs) in pharmaceutical sciences has expanded far beyond its original roots. The diverse range of opportunities offered by ISEs was broadly used in a number of pharmaceutical applications, with topics presented ranging from bioanalysis of drugs and metabolites, to protein binding studies, green analytical chemistry, impurity profiling, and drug dissolution in biorelevant media. Inspired from these advances and with the aim of extending the functional capabilities of ISEs, the primary focus of the present paper is the utilization of ISE as a tool in personalized medicine. Given the opportunity to explore biological events in real-time (such as drug metabolism) could be central to personalized medicine. (ATR) is a chemo-degradable and bio-degradable pharmaceutically active drug. Laudanosine (LDS) is the major degradation product and metabolite of ATR and is potentially toxic and reported to possess epileptogenic activity which increases the risk of convulsive effects. In this work, ATR have been subjected to both chemical and biological hydrolysis, and the course of the reactions is monitored by means of a ISE. In this study, we have designed an efficient real-time tracking strategy which substantially resolve the challenges of the ATR chemical and biological degradation kinetics. By utilizing a potentiometric sensor, tracking of ATR chemical and biological degradation kinetics can be performed in a very short time with excellent accuracy. The LOD was calculated to be 0.23 µ mol L−1, the potential drift was investigated over a period of 60 min and the value was 0.25 mV h−1. Real serum samples for measurement the rate of in vitro metabolism of ATR was performed. Furthermore, a full description of the fabricated screen-printed sensor was presented.

Suggested Citation

Ma’mun, Ahmed and Elrahman, Mohamed K. Abd and El-Kawy, Mohamed Abd, Real-Time Potentiometric Sensor; an Innovative Tool for Monitoring Hydrolysis of Chemo/Bio-Degradable Drugs in Pharmaceutical Sciences (May 6, 2018). J Pharm Biomed Anal. 2018 May 30;154:166-173, Available at SSRN: https://ssrn.com/abstract=3861134

Ahmed Ma’mun (Contact Author)

Heliopolis University - Faculty of Pharmacy ( email )

Egypt

Mohamed K. Abd Elrahman

Cairo University

Orman
Giza, 12613
Egypt

Mohamed Abd El-Kawy

Future University, Egypt

N 90th Street - Service Ln,
Fifth Settlement
New Cairo, Cairo Governorate
Egypt

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