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Disease Burden and Attributable Risk Factors of Alzheimer's Disease and Dementia in China from 1990 to 2019

34 Pages Posted: 19 Jul 2021

See all articles by Rui Li

Rui Li

Sun Yat-sen University (SYSU) - Department of Epidemiology

Jinlei Qi

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Center for Chronic and Noncommunicable Disease Control and Prevention

Yin Yang

Sun Yat-sen University (SYSU) - Department of Epidemiology

Yinglin Wu

Sun Yat-sen University (SYSU) - Department of Epidemiology

Yanpeng Yin

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Center for Chronic and Noncommunicable Disease Control and Prevention

Maigeng Zhou

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Center for Chronic and Noncommunicable Disease Control and Prevention

Zhengmin (Min) Qian

Saint Louis University - Department of Epidemiology and Biostatistics

Morgan H. LeBaige

Saint Louis University - Department of Epidemiology and Biostatistics

Stephen McMillin

Saint Louis University - School of Social Work

Hualiang Lin

Sun Yat-sen University (SYSU) - Department of Epidemiology

Haoyan Guo

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Center for Chronic and Noncommunicable Disease Control and Prevention

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Abstract

Background: Updated information on the burden of Alzheimer's disease and other forms of dementia are of great importance for evidence-based health care planning. However, such an estimate has been lacking in Chinese populations at both national and provincial levels.

Methods: The temporal trends and the attributable burdens of selected risk factors of Alzheimer's disease and dementia in China were reported through six indicators: incidence, mortality, prevalence, YLLs, YLDs, and DALYs.

Findings: There were notable increasing trends in the number of deaths (247·9%), incidence (264·8%), prevalence (296·5%), YLDs (308·7%), YLLs (201·7%) and DALYs (228·1%) from 1990 to 2019, respectively. The corresponding age-standardized rates increased by 6·2%, 19·3%, 33·6%, 33·4%, 3·1% and 10·7%. Smoking, high body mass index, high fasting plasma glucose levels, and metabolic risks were the four leading risk factors. Higher burden was observed among females versus males and in the more developed regions.

Interpretation: The disease burden in China were increasing substantially. Regional differences of the disease burden are accompanied by discrepancies of economic level and geographical location, as well as different levels of exposure to risk factors. Targeted prevention and control strategies are urgently needed to reduce the disease burden.

Funding: National key Research and Development program of China [2020YFC2008705].

Declaration of Interest: None to declare.

Keywords: Dementia; Alzheimer’s disease; disease burden; risk factors; China

Suggested Citation

Li, Rui and Qi, Jinlei and Yang, Yin and Wu, Yinglin and Yin, Yanpeng and Zhou, Maigeng and Qian, Zhengmin (Min) and LeBaige, Morgan H. and McMillin, Stephen and Lin, Hualiang and Guo, Haoyan, Disease Burden and Attributable Risk Factors of Alzheimer's Disease and Dementia in China from 1990 to 2019. Available at SSRN: https://ssrn.com/abstract=3889422 or http://dx.doi.org/10.2139/ssrn.3889422

Rui Li

Sun Yat-sen University (SYSU) - Department of Epidemiology ( email )

Guangzhou
China

Jinlei Qi

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Center for Chronic and Noncommunicable Disease Control and Prevention ( email )

Beijing 100050
China

Yin Yang

Sun Yat-sen University (SYSU) - Department of Epidemiology ( email )

China

Yinglin Wu

Sun Yat-sen University (SYSU) - Department of Epidemiology ( email )

Guangzhou
China

Yanpeng Yin

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Center for Chronic and Noncommunicable Disease Control and Prevention ( email )

Beijing 100050
China

Maigeng Zhou

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Center for Chronic and Noncommunicable Disease Control and Prevention ( email )

Beijing 100050
China
86 10 63040442 (Phone)

Zhengmin (Min) Qian

Saint Louis University - Department of Epidemiology and Biostatistics ( email )

United States

Morgan H. LeBaige

Saint Louis University - Department of Epidemiology and Biostatistics ( email )

United States

Stephen McMillin

Saint Louis University - School of Social Work ( email )

Saint Louis, MO
United States

Hualiang Lin (Contact Author)

Sun Yat-sen University (SYSU) - Department of Epidemiology ( email )

Guangzhou
China

Haoyan Guo

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Center for Chronic and Noncommunicable Disease Control and Prevention ( email )

Beijing 100050
China

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