Striatum Expresses Region-Specific Plasticity Consistent with Distinct Memory Abilities
62 Pages Posted: 20 Jul 2021 Publication Status: PublishedMore...
The striatum mediates two learning modalities: goal-directed behavior in dorsomedial (DMS) and habits in dorsolateral (DLS) striatum. The synaptic bases of these learnings are still elusive. Indeed, while ample research has described DLS plasticity, little remains known about DMS plasticity and its involvement in procedural learning. Here, we found symmetric and asymmetric anti-Hebbian spike-timing-dependent plasticity (STDP) in DMS and DLS, respectively, with opposite plasticity dominance upon increasing corticostriatal activity. During motor skill learning, plasticity was engaged in DMS and striatonigral DLS neurons only during early learning stages, whereas striatopallidal DLS neurons were mobilized only during late phases. We developed a mathematical model to study the computational properties of these rules in learning; we found that symmetric anti-Hebbian STDP favored memory flexibility by allowing a rapid learning of new patterns at the expense of maintenance, while asymmetric anti-Hebbian STDP favored memory maintenance, consistent with memory processes at play in procedural learning.
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