puc-header

Striatum Expresses Region-Specific Plasticity Consistent with Distinct Memory Abilities

62 Pages Posted: 20 Jul 2021 Publication Status: Published

See all articles by Sylvie Perez

Sylvie Perez

Université PSL - Dynamics and Pathophysiology of Neuronal Networks Team; Université Paris VI Pierre et Marie Curie - Center for Interdisciplinary Research in Biology (CIRB)

Yihui Cui

Université Paris VI Pierre et Marie Curie - Center for Interdisciplinary Research in Biology (CIRB)

Gaëtan Vignoud

Université Paris VI Pierre et Marie Curie - Center for Interdisciplinary Research in Biology (CIRB)

Elodie Perrin

Université Paris VI Pierre et Marie Curie - Center for Interdisciplinary Research in Biology (CIRB)

Alexandre Mendes

Université Paris VI Pierre et Marie Curie - Center for Interdisciplinary Research in Biology (CIRB)

Jonathan Touboul

Brandeis University

Laurent Venance

Université PSL - Dynamics and Pathophysiology of Neuronal Networks Team; Modelling and Analysis for Medical and Biological Applications (MAMBA)

More...

Abstract

The striatum mediates two learning modalities: goal-directed behavior in dorsomedial (DMS) and habits in dorsolateral (DLS) striatum. The synaptic bases of these learnings are still elusive. Indeed, while ample research has described DLS plasticity, little remains known about DMS plasticity and its involvement in procedural learning. Here, we found symmetric and asymmetric anti-Hebbian spike-timing-dependent plasticity (STDP) in DMS and DLS, respectively, with opposite plasticity dominance upon increasing corticostriatal activity. During motor skill learning, plasticity was engaged in DMS and striatonigral DLS neurons only during early learning stages, whereas striatopallidal DLS neurons were mobilized only during late phases. We developed a mathematical model to study the computational properties of these rules in learning; we found that symmetric anti-Hebbian STDP favored memory flexibility by allowing a rapid learning of new patterns at the expense of maintenance, while asymmetric anti-Hebbian STDP favored memory maintenance, consistent with memory processes at play in procedural learning.

Suggested Citation

Perez, Sylvie and Cui, Yihui and Vignoud, Gaëtan and Perrin, Elodie and Mendes, Alexandre and Touboul, Jonathan and Venance, Laurent, Striatum Expresses Region-Specific Plasticity Consistent with Distinct Memory Abilities. Available at SSRN: https://ssrn.com/abstract=3890377 or http://dx.doi.org/10.2139/ssrn.3890377
This version of the paper has not been formally peer reviewed.

Sylvie Perez

Université PSL - Dynamics and Pathophysiology of Neuronal Networks Team ( email )

Université Paris VI Pierre et Marie Curie - Center for Interdisciplinary Research in Biology (CIRB) ( email )

11 Place Marcellin Berthelot
Paris, 75005
France

Yihui Cui

Université Paris VI Pierre et Marie Curie - Center for Interdisciplinary Research in Biology (CIRB) ( email )

11 Place Marcellin Berthelot
Paris, 75005
France

Gaëtan Vignoud

Université Paris VI Pierre et Marie Curie - Center for Interdisciplinary Research in Biology (CIRB) ( email )

11 Place Marcellin Berthelot
Paris, 75005
France

Elodie Perrin

Université Paris VI Pierre et Marie Curie - Center for Interdisciplinary Research in Biology (CIRB)

11 Place Marcellin Berthelot
Paris, 75005
France

Alexandre Mendes

Université Paris VI Pierre et Marie Curie - Center for Interdisciplinary Research in Biology (CIRB) ( email )

11 Place Marcellin Berthelot
Paris, 75005
France

Jonathan Touboul

Brandeis University ( email )

415 South Street
Waltham, MA 02453
United States

HOME PAGE: http://blogs.brandeis.edu/mathneuro

Laurent Venance (Contact Author)

Université PSL - Dynamics and Pathophysiology of Neuronal Networks Team ( email )

Paris
France

Modelling and Analysis for Medical and Biological Applications (MAMBA) ( email )

Paris
France

Click here to go to Cell.com

Paper statistics

Abstract Views
409
Downloads
8
PlumX Metrics