Seroprevalence of Anti-Sars-Cov-2 Antibodies in Colombia, 2020: A Population-Based Study

44 Pages Posted: 18 Aug 2021

See all articles by Marcela Mercado-Reyes

Marcela Mercado-Reyes

Independent

Jeadran N. Malagón-Rojas

Doctorado en Salud Pública; Grupo de Salud Ambiental y Laboral - Instituto Nacional de Salud de Colombia

Silvana Zapata

Independent

Isabel Rodriguez-Barraquer

University of California, San Francisco (UCSF) - School of Medicine

Magdalena Wiesner

Independent

Yesith Guillermo Toloza-Pérez

Independent

Zulma M. Cucunubá

Imperial College London - MRC Centre for Global Infectious Disease Analysis

Juan P. Hernández-Ortíz

Independent

Jorge Acosta-Reyes

Independent

Maria I. Estupiñan

Independent

Marisol Galindo

Independent

Vivian V. Rubio

Independent

Lyda Muñoz-Galindo

Independent

Ericson Gabriel Osorio-Velázquez

Independent

Edgar A. Ibáñez-Pinilla

Independent

Eliana L Parra Barrera

Independent

Andrea del Pilar Bermúdez

Independent

Gianni G. Quinche

Independent

Gloria M. Puerto-Castro

Independent

Luis A. Villar

Universidad Industrial de Santander

Carlos Franco-Muñoz

Independent

Jaime Castellanos

Universidad El Bosque

Edgar Navarro-Lechuga

Universidad del Norte

Edna Margarita Valle

Independent

Nelson Pinto

Mangalore University - Department of Sociology, Students

Nancy Gore-Saravia

Independent

Juan Daniel OVIEDO ARANGO

Universidad del Rosario

Martha Lucía Ospina-Martínez

Independent

Maria C. Miranda

Independent

Date Written: July 21, 2021

Abstract

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to cause very high morbidity and mortality throughout Latin American countries. However, few population-based seroprevalence surveys have been conducted to quantify attack rates and characterize drivers of transmission.

Methods: We conducted a population-based cross-sectional study to assess the seroprevalence of antibodies against SARS-CoV-2 in ten cities in Colombia between September and December, 2020. The study involved multi-stage cluster sampling at each city. Participants provided a serum sample and answered a demographic and risk factor questionnaire. Prior infection by SARS-CoV-2 was ascertained using the "SARS-CoV-2 Total (COV2T) Advia Centaur - Siemens" chemiluminescence assay.

Findings: A total of 17863 participants from 7075 households participated in the study. Seroprevalence varied substantially between cities, ranging from 21% (95%CI 16-25%) in Medellín to 78% (95%CI 65-91%) in Guapi. There were no differences in seroprevalence by sex, but seropositivity was lower in adults 60 years or older and higher in certain ethnic groups. There was substantial heterogeneity in seroprevalence within cities, driven to a large extent by a strong association between socio-economic stratum and seropositivity.

Interpretation: Colombia has been one of the Latin American countries most affected by the COVID-19 pandemic. This study documented very high attack rates in several Colombian cities by the end of 2020 and identified key drivers of heterogeneities including ethnicity and socio-economic stratum. Few studies of seroprevalence of SARS-CoV-2 have been conducted in Latin America, and therefore this study contributes to the fundamental understanding of the pandemic in the region.

Note: Funding: The study was sponsored by, Ministerio de Ciencia y Tecnología e Innovación –CT361/2020-, Ministerio de Salud y Protección Social, Fundación Universitaria del Norte, Imperial College of London, Universidad Nacional de Colombia (Sede Medellín), Universidad de Córdoba, California University, Unidad Nacional de Gestión del Riesgo, Centro de Atención y Diagnóstico de Enfermedades Infecciosas -CDI-, Centro Internacional de Entrenamiento e Investigaciones Médicas -CIDEIM-, Departamento Administrativo Nacional de Estadística - DANE, Fondo Nacional de Turismo -FONTUR-, Secretarías de Salud Departamentales, Distritales y Municipales and Instituto Nacional de Salud. Besides the funding, the Ministerio de Ciencia y Tecnología e Innovación had no role in the study design, data collection, data analysis, data interpretation, or writing the report.

Declaration of Interests: All the authors declare no competing interests.

Ethics Approval Statement: The study proposal and protocol were approved by the ethics committee of Instituto Nacional de Salud (CEMIN 010/2020). We obtained written informed consent from each adult participant as well as oral assent and written parental permission from all participants between five and 17 years of age.

Keywords: SARS-CoV-2, Seroprevalence, COVID-19, Colombia, Public Health, population

Suggested Citation

Mercado-Reyes, Marcela and Malagón-Rojas, Jeadran N. and Zapata, Silvana and Rodriguez-Barraquer, Isabel and Wiesner, Magdalena and Toloza-Pérez, Yesith Guillermo and Cucunubá, Zulma M. and Hernández-Ortíz, Juan P. and Acosta-Reyes, Jorge and Estupiñan, Maria I. and Galindo, Marisol and Rubio, Vivian V. and Muñoz-Galindo, Lyda and Osorio-Velázquez, Ericson Gabriel and Ibáñez-Pinilla, Edgar A. and Parra Barrera, Eliana L and Bermúdez, Andrea del Pilar and Quinche, Gianni G. and Puerto-Castro, Gloria M. and Villar, Luis A. and Franco-Muñoz, Carlos and Castellanos, Jaime and Navarro-Lechuga, Edgar and Valle, Edna Margarita and Pinto, Nelson and Gore-Saravia, Nancy and OVIEDO ARANGO, Juan Daniel and Ospina-Martínez, Martha Lucía and Miranda, Maria C., Seroprevalence of Anti-Sars-Cov-2 Antibodies in Colombia, 2020: A Population-Based Study (July 21, 2021). Available at SSRN: https://ssrn.com/abstract=3890833 or http://dx.doi.org/10.2139/ssrn.3890833

Marcela Mercado-Reyes

Independent ( email )

Jeadran N. Malagón-Rojas (Contact Author)

Doctorado en Salud Pública ( email )

Avenida 9 #131a-20,
Bogota
Colombia

Grupo de Salud Ambiental y Laboral - Instituto Nacional de Salud de Colombia ( email )

Cuernavaca
Morelos
Mexico

Silvana Zapata

Independent ( email )

Isabel Rodriguez-Barraquer

University of California, San Francisco (UCSF) - School of Medicine ( email )

513 Parnassus Ave
San Francisco, CA 94143
United States

Magdalena Wiesner

Independent ( email )

Zulma M. Cucunubá

Imperial College London - MRC Centre for Global Infectious Disease Analysis ( email )

London
United Kingdom

Jorge Acosta-Reyes

Independent

Maria I. Estupiñan

Independent ( email )

Marisol Galindo

Independent ( email )

Vivian V. Rubio

Independent ( email )

Lyda Muñoz-Galindo

Independent ( email )

Eliana L Parra Barrera

Independent ( email )

Gianni G. Quinche

Independent ( email )

Gloria M. Puerto-Castro

Independent ( email )

Luis A. Villar

Universidad Industrial de Santander ( email )

Carrera 27 # 9
Bucaramanga, Santander 680002
Colombia

Carlos Franco-Muñoz

Independent ( email )

Jaime Castellanos

Universidad El Bosque ( email )

Edgar Navarro-Lechuga

Universidad del Norte ( email )

Km5 Via Puerto Colombia
Carrera 58 # 82-84 Apt 6B
Barranquilla
Colombia

Edna Margarita Valle

Independent ( email )

Nelson Pinto

Mangalore University - Department of Sociology, Students ( email )

India

Nancy Gore-Saravia

Independent ( email )

Juan Daniel OVIEDO ARANGO

Universidad del Rosario ( email )

Calle 12 No. 6-25
Bogota, DC
Colombia

Maria C. Miranda

Independent ( email )

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