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The Burden of COPD in China and its Provinces: Findings from the Global Burden of Disease Study 2019

33 Pages Posted: 26 Jul 2021

See all articles by Yanpeng Yin

Yanpeng Yin

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Center for Chronic and Noncommunicable Disease Control and Prevention

Jiayuan Wu

Guangdong Medical University - Department of Clinical Research

Lijun Wang

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Center for Chronic and Noncommunicable Disease Control and Prevention

Chaole Luo

Guangdong Medical University

Jiangmei Liu

Chinese Center for Disease Control and Prevention - Non-Communicable Disease Center

Yunning Liu

Chinese Center for Disease Control and Prevention

Jinlei Qi

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Center for Chronic and Noncommunicable Disease Control and Prevention

Weilin Zheng

Guangdong Medical University

Maigeng Zhou

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Center for Chronic and Noncommunicable Disease Control and Prevention

Tianwen Lai

Guangdong Medical University - Department of Pulmonary and Critical Care Medicine

More...

Abstract

Background: In China, chronic obstructive pulmonary disease (COPD) was accounted for a quarter of the global COPD population and has become a large economic burden. However, the comprehensive picture of the COPD burden, is not readily available for all of the provinces of China. 

Methods: Using the GBD 2019, we analyzed the incidence, prevalence, mortality, and disability-adjusted life years (DALYs) attributable to COPD across China and the corresponding time trends from 1990 to 2019, stratified by age and province. We also presented the contribution of risk factors to COPD-related mortality and DALYs. 

Findings: The absolute numbers of incidence and prevalence of COPD increased in 2019 as compared to in 1990, whereas the number of deaths and DALYs owing to COPD decreased from 1990 to 2019. The age-standardized rates (ASRs) of COPD burden continuously decreased from 1990 to 2019. The crude rates of COPD burden dramatically increased with age, and reached a peak at the age group of older than 95 years. In 2019, smoking was the most common risk factor for COPD mortality and DALYs in the whole population, but the most significant risk factor in females was ambient particulate matter pollution. At the provincial level, the ASRs of COPD burden were significantly associated with the SDIs, with the highest ASRs in the western provinces with low SDIs. 

Interpretation: China has a disproportionately high burden of COPD, suggesting that geographically targeted considerations should be developed to enhance COPD health and reduce the COPD burden throughout China and in specific provinces.

Funding: This work is supported by the Guangdong Basic and Applied Basic Research Foundation (No. 2020B1515020004, No. 2021A1515011056), the National Natural Science Foundation of China (81873404); Project of Young Innovative Talents in Colleges and Universities in Guangdong Province (No. 2018KQNCX095), Affiliated Hospital of Guangdong Medical University Clinical Research Program (LCYJ2018C001, LCYJ2019B011).

Declaration of Interest: We declare no competing interests.

Keywords: chronic obstructive pulmonary disease; epidemiology; secular trend; China; Global Burden of Disease

Suggested Citation

Yin, Yanpeng and Wu, Jiayuan and Wang, Lijun and Luo, Chaole and Liu, Jiangmei and Liu, Yunning and Qi, Jinlei and Zheng, Weilin and Zhou, Maigeng and Lai, Tianwen, The Burden of COPD in China and its Provinces: Findings from the Global Burden of Disease Study 2019. Available at SSRN: https://ssrn.com/abstract=3893540 or http://dx.doi.org/10.2139/ssrn.3893540

Yanpeng Yin

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Center for Chronic and Noncommunicable Disease Control and Prevention ( email )

Beijing 100050
China

Jiayuan Wu

Guangdong Medical University - Department of Clinical Research ( email )

620 Renmin N Rd, Yuexiu Qu
Guangzhou Shi
Guangdong Sheng, 510000
China

Lijun Wang

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Center for Chronic and Noncommunicable Disease Control and Prevention ( email )

Beijing 100050
China

Chaole Luo

Guangdong Medical University ( email )

620 Renmin N Rd, Yuexiu Qu
Guangzhou Shi
Guangdong Sheng, 510000
China

Jiangmei Liu

Chinese Center for Disease Control and Prevention - Non-Communicable Disease Center ( email )

Beijing 100050
China

Yunning Liu

Chinese Center for Disease Control and Prevention

155 Changbai Road
Changping District
Beijing, Changping District 102206
China

Jinlei Qi

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Center for Chronic and Noncommunicable Disease Control and Prevention ( email )

Beijing 100050
China

Weilin Zheng

Guangdong Medical University ( email )

620 Renmin N Rd, Yuexiu Qu
Guangzhou Shi
Guangdong Sheng, 510000
China

Maigeng Zhou

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Center for Chronic and Noncommunicable Disease Control and Prevention ( email )

Beijing 100050
China

Tianwen Lai (Contact Author)

Guangdong Medical University - Department of Pulmonary and Critical Care Medicine ( email )

Zhanjiang
China

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