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The Landscape of Host-Microbiota Interactions at the Ocular Mucosa

56 Pages Posted: 29 Jul 2021 Publication Status: Review Complete

See all articles by Qiaoxing Liang

Qiaoxing Liang

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Bin Zou

Sun Yat-Sen University - State Key Laboratory of Ophthalmology

Xifang Li

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Xiuli Deng

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Jing Li

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Ren Liu

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Yanli Zou

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Xiao Hu

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Shixin Guo

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Juanran Liang

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Tingting Chen

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Yuxin Zhang

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Xiaofeng Wen

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Xiaohu Ding

Sun Yat-sen University - State Key Laboratory of Ophthalmology

Zhenhai Zhang

Southern Medical University - State Key Laboratory of Organ Failure Research

Jin-Xin Bei

Sun Yat-sen University (SYSU) - Sun Yat-Sen University Cancer Center

Haotian Lin

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Mingguang He

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Lingyi Liang

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Lai Wei

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

More...

Abstract

Characterization of host-microbiota interactions at mucosal surfaces is essential for understanding the role of microbial dysbiosis in the pathogenesis of immune-mediated diseases. However, identifying the microbe-specific mucosal immune response in humans has challenges in distinguishing microorganisms that directly interact with the mucosa and capturing local host responses to them. Here, we performed a paralleled analysis on host gene expression and microbiota activity profiles of 436 conjunctival metatranscriptomes from 109 monozygotic twin pairs. Our within-twin-pair analysis revealed associations between the activity of microbial species and immune cells, cytokines, and human leukocyte antigens, while excluding the influence of host genetics and the environment . We further identified an association of Gordonia bronchialis with ocular graft-versus-host disease (GVHD) by surveying conjunctival metagenomes from 124 individuals and analyzed the putative role of this species in GVHD, demonstrating potential implications of the microbial species-specific human mucosal responses in investigating the etiology of immune-mediated diseases.

Suggested Citation

Liang, Qiaoxing and Zou, Bin and Li, Xifang and Deng, Xiuli and Li, Jing and Liu, Ren and Zou, Yanli and Hu, Xiao and Guo, Shixin and Liang, Juanran and Chen, Tingting and Zhang, Yuxin and Wen, Xiaofeng and Ding, Xiaohu and Zhang, Zhenhai and Bei, Jin-Xin and Lin, Haotian and He, Mingguang and Liang, Lingyi and Wei, Lai, The Landscape of Host-Microbiota Interactions at the Ocular Mucosa. Available at SSRN: https://ssrn.com/abstract=3895932 or http://dx.doi.org/10.2139/ssrn.3895932
This version of the paper has not been formally peer reviewed.

Qiaoxing Liang

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Bin Zou

Sun Yat-Sen University - State Key Laboratory of Ophthalmology ( email )

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Xifang Li

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Xiuli Deng

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Jing Li

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Ren Liu

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Yanli Zou

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Xiao Hu

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Shixin Guo

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Juanran Liang

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Tingting Chen

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Yuxin Zhang

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Xiaofeng Wen

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Xiaohu Ding

Sun Yat-sen University - State Key Laboratory of Ophthalmology ( email )

Zhenhai Zhang

Southern Medical University - State Key Laboratory of Organ Failure Research ( email )

Guangzhou, Guangdong Province
China

Jin-Xin Bei

Sun Yat-sen University (SYSU) - Sun Yat-Sen University Cancer Center ( email )

Guangzhou
China

Haotian Lin

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Mingguang He

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Lingyi Liang

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Lai Wei (Contact Author)

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

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