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Modification Effect of Changes in Cardiometabolic Traits in the Association between History of Kidney Stones and Cardiovascular Diseases Events

33 Pages Posted: 6 Aug 2021

See all articles by Min Xu

Min Xu

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Zhiyun Zhao

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Feixia Shen

Wenzhou Medical University - First Affiliated Hospital

Ruying Hu

Zhejiang Provincial Center for Disease Control and Prevention - Department of Non-Communicable Disease Control and Prevention

Jieli Lu

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Yu Xu

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Tiange Wang

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Mian Li

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Gang Chen

Fujian Medical University - Department of Endocrinology; Fujian Academy of Medical Sciences - Fujian Provincial Key Laboratory of Medical Analysis

Lulu Chen

Huazhong University of Science and Technology - Tongji Medical College

Yuhong Chen

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Huacong Deng

Chongqing Medical University - First Affiliated Hospital

Zhengnan Gao

Dalian University - Dalian Municipal Central Hospital

Yanan Huo

Nanchang University - Jiangxi Medical School

Qiang Li

Harbin Medical University - Second Affiliated Hospital

Chao Liu

Jiangsu Province Hospital on Integration of Chinese and Western Medicine

Zuojie Luo

Guangxi Medical University - First Affiliated Hospital

Yiming Mu

Chinese PLA General Hospital - Department of Endocrinology

Guijun Qin

Zhengzhou University - Division of Endocrinology

Yingfen Qin

Guangxi Medical University

Lixin Shi

Guizhou Medical University (Guiyang Medical University) - First Affiliated Hospital

Qing Su

Shanghai Jiao Tong University (SJTU) - Department of Endocrinology

Qin Wan

Southwest Medical University - Affiliated Hospital

Guixia Wang

Jilin University (JLU) - Department of Endocrinology and Metabolism

Shuangyuan Wang

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Youmin Wang

Anhui Medical University - Department of Endocrinology

Shengli Wu

Government of the People's Republic of China - Karamay Municipal People's Hospital

Yiping Xu

Shanghai Jiao Tong University (SJTU)

Li Yan

Sun Yat-sen University (SYSU) - Sun Yat-sen Memorial Hospital

Tao Yang

Nanjing Medical University - Nanjing Medical Hospital

Zhen Ye

Zhejiang Provincial Center for Disease Control and Prevention

Xue-Feng Yu

Huazhong University of Science and Technology - Tongji Medical College

Yinfei Zhang

Central Hospital of Shanghai Jiading District

Jiajun Zhao

Shandong First Medical University - Science and Technology Innovation Center; Shandong First Medical University - Department of Endocrinology and Metabolism; Shandong Academy of Clinical Medicine - Institute of Endocrinology; Shandong Clinical Medical Center of Endocrinology and Metabolism

Tianshu Zeng

Huazhong University of Science and Technology - Department of Endocrinology

Weiqing Wang

Shanghai Jiao Tong University (SJTU) - Shanghai Clinical Center for Endocrine and Metabolic Diseases

Yufang Bi

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Xulei Tang

Lanzhou University - Department of Endocrinology

Guang Ning

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

4C Study Group

Independent

More...

Abstract

Background: We investigated the modification effect of status changes in metabolic syndrome (MetS) on the association of a kidney stones history with risk of major CVD events.

Methods: We performed a prospective association and interaction study in a nationwide cohort including 129172 participants aged ≥ 40 years without CVDs at baseline and followed up for an average of 3·8 years. Kidney stones information was collected by using a questionnaire and validated by medical records. The repeated biochemical measurements were performed to ascertain the metabolic status at both baseline and follow-up.

Findings: The presence rate of kidney stones was 4·28% in 44,958 men and 2·68% in 84,214 women. 4,017 incident total CVDs were documented and ascertained. Kidney stones were significantly associated with 44%, 70% and 31% higher risk of CVDs, coronary heart disease and stroke, respectively, after adjustments for traditional risk factors of CVDs. Interestingly, stratified analysis showed that significant associations were found in the incident and the sustained MetS patients, while no significant associations were found in the non-MetS at both baseline and follow-up or the MetS remission ones. For change status of each single component of the MetS, though the trends were not always the same, the associations were consistently significant in those with sustained metabolic disorders.

Interpretation: A kidney stones history in women with newly developed or long-standing MetS associate with an increased risk of CVD. The mechanisms link kidney stones and CVD risk in the metabolic and non-metabolic pathways were warranted for further studies.

Funding: This work was funded by the National Key R&D Program of China (2018YFC1311705, 2016YFC1305600, 2016YFC1305202, 2016YFC1304904, 2017YFC1310700 and 2018YFC1311800), the National Natural Science Foundation of China (81941017, 81970706, 81970728, 81870560, 81730023 and 81770842), the National Major Scientific and Technological Special Project for “Significant New Drugs Development” (2017ZX09304007), the Shanghai Science and Technology Commission (YDZX2017310000488) and the Clinical Research Plan of SHDC (SHDC2020CR1001A and SHDC2020CR3069B), and the Shanghai Municipal Education Commission–Gaofeng Clinical Medicine Grant Support (20152508 Round 2). M. X., J. L., M. L., T.W., Y. X., Z. Z., Y. B., W. W., and G. N. are members of innovative research team of high-level local universities in Shanghai.

Declaration of Interest: We declare no competing interests.

Ethical Approval: The study was approved by the Medical Ethics Committee of Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine.

Keywords: Kidney stone, CVD, metabolic disorders, modification effect, longitudinal change

Suggested Citation

Xu, Min and Zhao, Zhiyun and Shen, Feixia and Hu, Ruying and Lu, Jieli and Xu, Yu and Wang, Tiange and Li, Mian and Chen, Gang and Chen, Lulu and Chen, Yuhong and Deng, Huacong and Gao, Zhengnan and Huo, Yanan and Li, Qiang and Liu, Chao and Luo, Zuojie and Mu, Yiming and Qin, Guijun and Qin, Yingfen and Shi, Lixin and Su, Qing and Wan, Qin and Wang, Guixia and Wang, Shuangyuan and Wang, Youmin and Wu, Shengli and Xu, Yiping and Yan, Li and Yang, Tao and Ye, Zhen and Yu, Xue-Feng and Zhang, Yinfei and Zhao, Jiajun and Zeng, Tianshu and Wang, Weiqing and Bi, Yufang and Tang, Xulei and Ning, Guang and Group, 4C Study, Modification Effect of Changes in Cardiometabolic Traits in the Association between History of Kidney Stones and Cardiovascular Diseases Events. Available at SSRN: https://ssrn.com/abstract=3900408 or http://dx.doi.org/10.2139/ssrn.3900408

Min Xu

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

Zhiyun Zhao

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Shanghai
China

Feixia Shen

Wenzhou Medical University - First Affiliated Hospital

Wenzhou, Zhejiang Province
China

Ruying Hu

Zhejiang Provincial Center for Disease Control and Prevention - Department of Non-Communicable Disease Control and Prevention ( email )

Hangzhou
China

Jieli Lu

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Shanghai
China

Yu Xu

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Shanghai
China

Tiange Wang

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Shanghai
China

Mian Li

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Shanghai
China

Gang Chen

Fujian Medical University - Department of Endocrinology ( email )

China
+86-1350933707 (Phone)

Fujian Academy of Medical Sciences - Fujian Provincial Key Laboratory of Medical Analysis

China

Lulu Chen

Huazhong University of Science and Technology - Tongji Medical College ( email )

Yuhong Chen

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Huacong Deng

Chongqing Medical University - First Affiliated Hospital

Chongqing
China

Zhengnan Gao

Dalian University - Dalian Municipal Central Hospital

Dalian
China

Yanan Huo

Nanchang University - Jiangxi Medical School

Nanchang, 330000
China

Qiang Li

Harbin Medical University - Second Affiliated Hospital

Harbin
China

Chao Liu

Jiangsu Province Hospital on Integration of Chinese and Western Medicine

Nanjing
China

Zuojie Luo

Guangxi Medical University - First Affiliated Hospital

Guangxi, 530021
China

Yiming Mu

Chinese PLA General Hospital - Department of Endocrinology

Beijing, 100853
China

Guijun Qin

Zhengzhou University - Division of Endocrinology ( email )

Yingfen Qin

Guangxi Medical University ( email )

22 Shuangyong Rd
Qingxiu Qu, Nanning Shi
Guangxi Zhuangzuzizhiqu, 530021
China

Lixin Shi

Guizhou Medical University (Guiyang Medical University) - First Affiliated Hospital

Guiyang, Guizhou 550004
China

Qing Su

Shanghai Jiao Tong University (SJTU) - Department of Endocrinology ( email )

Shanghai
China

Qin Wan

Southwest Medical University - Affiliated Hospital

China

Guixia Wang

Jilin University (JLU) - Department of Endocrinology and Metabolism ( email )

China

Shuangyuan Wang

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

Youmin Wang

Anhui Medical University - Department of Endocrinology

Hefei, Anhui 230000
China

Shengli Wu

Government of the People's Republic of China - Karamay Municipal People's Hospital

Xinjiang
China

Yiping Xu

Shanghai Jiao Tong University (SJTU)

KoGuan Law School
Shanghai 200030, Shanghai 200052
China

Li Yan

Sun Yat-sen University (SYSU) - Sun Yat-sen Memorial Hospital

Guangzhou
China

Tao Yang

Nanjing Medical University - Nanjing Medical Hospital

Nanjing
China

Zhen Ye

Zhejiang Provincial Center for Disease Control and Prevention

Binjiang
Hangzhou, Zhejiang 310051
China

Xue-Feng Yu

Huazhong University of Science and Technology - Tongji Medical College ( email )

Yinfei Zhang

Central Hospital of Shanghai Jiading District

Shanghai
China

Jiajun Zhao

Shandong First Medical University - Science and Technology Innovation Center ( email )

Jinan, Shandong
China

Shandong First Medical University - Department of Endocrinology and Metabolism ( email )

China

Shandong Academy of Clinical Medicine - Institute of Endocrinology ( email )

China

Shandong Clinical Medical Center of Endocrinology and Metabolism ( email )

China

Tianshu Zeng

Huazhong University of Science and Technology - Department of Endocrinology

Wuhan, Hubei 430022
China

Weiqing Wang

Shanghai Jiao Tong University (SJTU) - Shanghai Clinical Center for Endocrine and Metabolic Diseases ( email )

Shanghai
China

Yufang Bi

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Shanghai
China

Xulei Tang

Lanzhou University - Department of Endocrinology

Lanzhou, Gansu 730000
China

Guang Ning (Contact Author)

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

4C Study Group

Independent

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