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Effect of a Nutritional Support System to Increase Survival and Reduce Mortality in Patients with COVID-19 in Stage III and Comorbidities: A Blinded Randomized Controlled Clinical Trial.

18 Pages Posted: 25 Oct 2021

See all articles by Fernando Leal

Fernando Leal

Anahuac University - Centro de Investigación en Ciencias de la Salud (CICSA)

Alejandra Garcia

Anahuac University

Lorena del Carmen Abarca

Anahuac University

Dinnaru Gonzalez

Anahuac University

Georgina Cruz

Anahuac University

Marco Montell

Anahuac University

Antonio Ibarra

Anahuac University

More...

Abstract

The COVID-19 evolution depends on immunological capacity. The global hospital mortality rate is 15-20%, but in México it is 46%. There are several therapeutic protocols, however, integral nutrition is not considered. In this study, a Nutritional Support System (NSS) was employed to increase survival and reduce mortality in patients with stage III COVID-19. A randomized, blinded, controlled clinical trial was performed. Eighty patients (aged 30 to 75 years, both sexes) were assigned to 1) “Control Group” (CG) hospital diet and medical treatment or 2) “Intervention Group” (IG) hospital diet, medical treatment, and the NSS (vitamins, minerals, fiber, omega-3, amino acids, B-complex, and probiotics). IG significantly increased survival and reduced mortality compared to CG (p=0·027). IG decreased progression to Mechanical Ventilation Assistance (MVA) by 10%, reduced the intubation period by 15 days, and increased survival in intubated patients by 38% compared to CG. IG showed improvement compared to CG in: decrease of supplemental oxygen (p=0·014), the qSOFA test (p=0·040), constipation (p=0·014), the PHQ-9 test (p=0·003), and in the follow-up, saturation with oxygen (p=0·030). The NSS increases survival and decreases mortality in patients with stage III COVID-19.

Trial Registration: Clinical Trials registration code: NCT 04507867.

Funding: This research was funded by Centro de Investigación en Ciencias de la Salud (CICSA),
Universidad Anáhuac México Campus Norte grant number 2017/202036.

Declaration of Interest: The authors declare that they have no conflicts of interest.

Ethical Approval: The study was conducted according to the guidelines of the Declaration of Helsinki, the Nuremberg Code, and the Mexican Standard NOM-012-SSA3-2012. The research was approved by the research committee of the Faculty of Health Sciences of the Universidad Anáhuac México Norte, registration number: 202036, CONBIOETICA-15-CEI-004- 20160729, the research committee of the CMI Toluca, registration number: 207C0401010201S / JIC / 155/2020

Keywords: COVID-19, SARS-COV-2, Nutritional Support, NSS, Nutrition, Supplementation, Probiotics, Pneumonia, Survival, Mortality

Suggested Citation

Leal, Fernando and Garcia, Alejandra and Abarca, Lorena del Carmen and Gonzalez, Dinnaru and Cruz, Georgina and Montell, Marco and Ibarra, Antonio, Effect of a Nutritional Support System to Increase Survival and Reduce Mortality in Patients with COVID-19 in Stage III and Comorbidities: A Blinded Randomized Controlled Clinical Trial.. Available at SSRN: https://ssrn.com/abstract=3949424 or http://dx.doi.org/10.2139/ssrn.3949424

Fernando Leal (Contact Author)

Anahuac University - Centro de Investigación en Ciencias de la Salud (CICSA) ( email )

Mexico City
Mexico

Alejandra Garcia

Anahuac University ( email )

Mexico

Lorena del Carmen Abarca

Anahuac University ( email )

Mexico

Dinnaru Gonzalez

Anahuac University ( email )

Mexico

Georgina Cruz

Anahuac University ( email )

Mexico

Marco Montell

Anahuac University ( email )

Mexico

Antonio Ibarra

Anahuac University ( email )

Mexico

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