Antibacterial,Antifungal Chalcone derivatives as EGFR Inhibitors-Molecular docking and ADMET Studies

Antibacterial,Antifungal Chalcone Derivatives as EGFR Inhibitors-Molecular Docking nd ADMET Studies.,Hemalatha Sattu ,Indira Rani Neralla,Saritha Jyotsna Tangeda.;JPRI,33(45B):387-396,2021;Article no.JPRI.74657

11 Pages Posted: 18 Nov 2021

See all articles by Hemalatha sattu

Hemalatha sattu

affiliation not provided to SSRN

Date Written: November 9, 2021

Abstract

In our earlier research, we have synthesized series of substituted 1-(2, 5-dimethyl thiophene-3yl)-(4-substituted phenyl)-2-propene-1-one derivatives and evaluated them for their anti-bacterial and antifungal activity. In recent years, chalcone derivatives are proved for their varied pharmacological effects ranging from antimicrobial activity to anti-cancer effects. In this study, we have hypothesized the efficiency of our earlier synthesized anti-bacterial and antifungal chalcone derivatives for their potential inhibition of epidermal growth factor receptor protein (EGFR), through molecular docking studies.

Keywords: EGFR;Chalcones;Molecular Docking;Binding Energy;ADME

Suggested Citation

sattu, Hemalatha, Antibacterial,Antifungal Chalcone derivatives as EGFR Inhibitors-Molecular docking and ADMET Studies (November 9, 2021). Antibacterial,Antifungal Chalcone Derivatives as EGFR Inhibitors-Molecular Docking nd ADMET Studies.,Hemalatha Sattu ,Indira Rani Neralla,Saritha Jyotsna Tangeda.;JPRI,33(45B):387-396,2021;Article no.JPRI.74657, Available at SSRN: https://ssrn.com/abstract=3959634

Hemalatha Sattu (Contact Author)

affiliation not provided to SSRN

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