Antibacterial,Antifungal Chalcone derivatives as EGFR Inhibitors-Molecular docking and ADMET Studies
Antibacterial,Antifungal Chalcone Derivatives as EGFR Inhibitors-Molecular Docking nd ADMET Studies.,Hemalatha Sattu ,Indira Rani Neralla,Saritha Jyotsna Tangeda.;JPRI,33(45B):387-396,2021;Article no.JPRI.74657
11 Pages Posted: 18 Nov 2021
Date Written: November 9, 2021
In our earlier research, we have synthesized series of substituted 1-(2, 5-dimethyl thiophene-3yl)-(4-substituted phenyl)-2-propene-1-one derivatives and evaluated them for their anti-bacterial and antifungal activity. In recent years, chalcone derivatives are proved for their varied pharmacological effects ranging from antimicrobial activity to anti-cancer effects. In this study, we have hypothesized the efficiency of our earlier synthesized anti-bacterial and antifungal chalcone derivatives for their potential inhibition of epidermal growth factor receptor protein (EGFR), through molecular docking studies.
Keywords: EGFR;Chalcones;Molecular Docking;Binding Energy;ADME
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