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Sex Differences in Aged 80 and Over Hospitalized Patients with Community-Acquired UTI: A Prospective Observational Study

16 Pages Posted: 19 Nov 2021 Publication Status: Published

See all articles by Ian López Cruz

Ian López Cruz

Doctor Peset University Hospital - Internal Medicine Department

Ana Esparcia

Dr. Peset University Hospital - Department of Internal Medicine

Manel Madrazo

Internal Medicine Department, Dr. Peset University Hospital

Juan Alberola Enguídanos

The University of Valencia - Department of Microbiology

José María Eiros

University of Valladolid - Department of Microbiology and Parasitology

Arturo Artero

Dr. Peset University Hospital - Department of Internal Medicine

Abstract

Aim This study aimed to evaluate clinically significant sex differences in urinary tract infection (UTI) in aged 80 and over hospitalized patients with community-acquired UTI.
Methods
This was a prospective study of 161 patients aged 80 and over admitted to hospital with community-acquired UTI. Epidemiological, clinical, laboratory and microbiologic variables were compared between both sexes. Multivariate analysis was performed using logistic regression to determine the variables independently associated with sex.
Results
In a population of 91 (56.52%) women and 70 (43.48%) men, aged 80 and over, we found that women were more likely to have cognitive impairment (p = 0.035) and less likely to have chronic obstructive pulmonary disease (COPD) (p = 0.006) and indwelling urinary catheter (p < 0.001) than men. Levels of creatinine were higher in men than in women (p = 0.008). Septic shock at presentation was more frequent in the male group (p = 0.043). Men had a higher rate of polymicrobial infection (p = 0.035) and Pseudomonas aeruginosa infection (p = 0.003). Factors independently associated with sex by multivariate analysis were septic shock, cognitive impairment, COPD and indwelling urinary catheter.
Conclusion
Men aged 80 and over with community-acquired UTI had more septic shock at admission to hospital and higher rates of indwelling urinary catheter, while women had more cognitive impairment. There were no differences in outcomes between sexes.

Keywords: Aged 80 and over, community acquired infections, Sex differences, sepsis, Urinary tract infection

Suggested Citation

López Cruz, Ian and Esparcia, Ana and Madrazo, Manel and Alberola Enguídanos, Juan and Eiros, José María and Artero, Arturo, Sex Differences in Aged 80 and Over Hospitalized Patients with Community-Acquired UTI: A Prospective Observational Study. Available at SSRN: https://ssrn.com/abstract=3966914 or http://dx.doi.org/10.2139/ssrn.3966914

Ian López Cruz

Doctor Peset University Hospital - Internal Medicine Department ( email )

Valencia 46017
Spain

Ana Esparcia

Dr. Peset University Hospital - Department of Internal Medicine ( email )

Spain

Manel Madrazo

Internal Medicine Department, Dr. Peset University Hospital ( email )

Juan Alberola Enguídanos (Contact Author)

The University of Valencia - Department of Microbiology ( email )

Valencia
Spain

José María Eiros

University of Valladolid - Department of Microbiology and Parasitology ( email )

Spain

Arturo Artero

Dr. Peset University Hospital - Department of Internal Medicine ( email )

Spain

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