Breakthrough Infections with SARS-CoV-2 Omicron Variant Despite Booster Dose of mRNA Vaccine

8 Pages Posted: 10 Dec 2021 Last revised: 21 Jan 2022

See all articles by Constanze Kuhlmann

Constanze Kuhlmann

Division of Hand, Plastic and Aesthetic Surgery, LMU Klinikum, Ludwig-Maximilians-Universität München

Carla Konstanze Mayer

Independent

Mathilda Claassen

NHLS Tygerberg

Tongai G. Maponga

Stellenbosch University

Andrew D. Sutherland

Stellenbosch University - Faculty of Medicine and Health Sciences

Tasnim Suliman

University of the Western Cape

Megan Shaw

University of the Western Cape

Wolfgang Preiser

Division of Medical Virology

Date Written: December 9, 2021

Abstract

Based on its genetic profile and preliminary in vitro and epidemiological data, the recently emerged SARS-CoV-2 Omicron variant is predicted to evade immune responses to some extent. We report a cluster of Omicron variant infections in individuals who had received full primary vaccination series and booster doses with mRNA vaccines. All patients experienced symptomatic COVID-19 but clinical manifestations were mild to moderate. Their SARS-CoV-2 viral RNA loads and anti-spike antibody levels were determined. This series proves that even three doses of mRNA vaccines may not be sufficient to prevent infection and symptomatic disease with the Omicron variant.

Note:
Funding Information: Funding was provided by South African Medical Research Council, Poliomyelitis Research Foundation and National Health Laboratory Service Research Trust

Conflict of Interests: Wolfgang Preiser serves as member of the South African Ministerial Advisory Committee on COVID-19 Vaccines. All other others declare no conflict of interests.

Ethical Approval: The investigation was approved by the Health Research Ethics Committee of Stellenbosch University (REFERENCE NUMBER TO BE INSERTED ONCE AVAILABLE) and all participants provided informed consent.

Keywords: SARS-CoV-2, Omicron variant, B.1.1.529, vaccine breakthrough infection, booster vaccination, COVID-19, mRNA vaccine

Suggested Citation

Kuhlmann, Constanze and Mayer, Carla Konstanze and Claassen, Mathilda and Maponga, Tongai G. and Sutherland, Andrew D. and Suliman, Tasnim and Shaw, Megan and Preiser, Wolfgang, Breakthrough Infections with SARS-CoV-2 Omicron Variant Despite Booster Dose of mRNA Vaccine (December 9, 2021). Available at SSRN: https://ssrn.com/abstract=3981711 or http://dx.doi.org/10.2139/ssrn.3981711

Constanze Kuhlmann

Division of Hand, Plastic and Aesthetic Surgery, LMU Klinikum, Ludwig-Maximilians-Universität München ( email )

Ziemsenstrasse 5
Munich, DE Bavaria 80336
Germany

Carla Konstanze Mayer

Independent ( email )

Mathilda Claassen

NHLS Tygerberg ( email )

Division of Medical Virology
Cape Town
South Africa
+27828799020 (Phone)

Tongai G. Maponga

Stellenbosch University

Stellenbosch, Western Cape
South Africa

Andrew D. Sutherland

Stellenbosch University - Faculty of Medicine and Health Sciences ( email )

Tygerberg
South Africa

Tasnim Suliman

University of the Western Cape ( email )

Robert Sobukwe Road
Bellville, 7535
South Africa

Megan Shaw

University of the Western Cape ( email )

Robert Sobukwe Road
Bellville, 7535
South Africa

Wolfgang Preiser (Contact Author)

Division of Medical Virology ( email )

Tygerberg
South Africa
+27219389353 (Phone)

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