Comparative Effectiveness of mRNA and Inactivated Whole Virus Vaccines against COVID-19 Infection and Severe Disease in Singapore

Abstract

We compared the incidence rates of COVID-19 infection and severe disease among adults who had received two doses of Pfizer-BioNTech/Comirnaty, Moderna, Sinovac-CoronaVac and Sinopharm vaccines in Singapore. Individuals vaccinated with inactivated whole virus vaccines were observed to have lower protection compared with those vaccinated with mRNA vaccines.

Note:
Funding: This study was not funded.

Declaration of Interests: The authors declare that they have no conflict of interest.

Ethics Approval Statement: This study was conducted as part of national COVID-19 public health response under the Infectious Disease Act, Ministry of Health, Singapore, with exemption from ethics review, as provided for under the Human Biomedical Research Act 2015, Singapore.

Keywords: COVID-19, SARS-CoV-2, vaccines, mRNA vaccine, inactivated vaccine