Comparative Effectiveness of mRNA and Inactivated Whole Virus Vaccines against COVID-19 Infection and Severe Disease in Singapore
13 Pages Posted: 5 Jan 2022
Date Written: December 28, 2021
We compared the incidence rates of COVID-19 infection and severe disease among adults who had received two doses of Pfizer-BioNTech/Comirnaty, Moderna, Sinovac-CoronaVac and Sinopharm vaccines in Singapore. Individuals vaccinated with inactivated whole virus vaccines were observed to have lower protection compared with those vaccinated with mRNA vaccines.
Funding: This study was not funded.
Declaration of Interests: The authors declare that they have no conflict of interest.
Ethics Approval Statement: This study was conducted as part of national COVID-19 public health response under the Infectious Disease Act, Ministry of Health, Singapore, with exemption from ethics review, as provided for under the Human Biomedical Research Act 2015, Singapore.
Keywords: COVID-19, SARS-CoV-2, vaccines, mRNA vaccine, inactivated vaccine
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