Comparative Effectiveness of mRNA and Inactivated Whole Virus Vaccines against COVID-19 Infection and Severe Disease in Singapore

13 Pages Posted: 5 Jan 2022

See all articles by Premikha M

Premikha M

Ministry of Health, Singapore

Calvin J. Chiew

National Centre for Infectious Diseases, Singapore; Ministry of Health, Singapore

Wycliffe E. Wei

National Public Health and Epidemiology Unit, National Centre for Infectious Diseases

Yee-Sin Leo

National Centre for Infectious Diseases - Infectious Disease Research and Training Office

Benjamin Ong

Ministry of Health, Singapore

David Chien Lye

National Centre for Infectious Diseases

Vernon J. Lee

Ministry of Health, Singapore

Kelvin Bryan Tan

Ministry of Health, Singapore

Date Written: December 28, 2021

Abstract

We compared the incidence rates of COVID-19 infection and severe disease among adults who had received two doses of Pfizer-BioNTech/Comirnaty, Moderna, Sinovac-CoronaVac and Sinopharm vaccines in Singapore. Individuals vaccinated with inactivated whole virus vaccines were observed to have lower protection compared with those vaccinated with mRNA vaccines.

Note:
Funding: This study was not funded.

Declaration of Interests: The authors declare that they have no conflict of interest.

Ethics Approval Statement: This study was conducted as part of national COVID-19 public health response under the Infectious Disease Act, Ministry of Health, Singapore, with exemption from ethics review, as provided for under the Human Biomedical Research Act 2015, Singapore.

Keywords: COVID-19, SARS-CoV-2, vaccines, mRNA vaccine, inactivated vaccine

Suggested Citation

M, Premikha and Chiew, Calvin J. and Wei, Wycliffe E. and Leo, Yee-Sin and Ong, Benjamin and Lye, David Chien and Lee, Vernon J. and Tan, Kelvin Bryan, Comparative Effectiveness of mRNA and Inactivated Whole Virus Vaccines against COVID-19 Infection and Severe Disease in Singapore (December 28, 2021). Available at SSRN: https://ssrn.com/abstract=3995282 or http://dx.doi.org/10.2139/ssrn.3995282

Premikha M (Contact Author)

Ministry of Health, Singapore ( email )

College of Medicine
16 College Road
Singapore, 169854
Singapore

Calvin J. Chiew

National Centre for Infectious Diseases, Singapore

Singapore

Ministry of Health, Singapore ( email )

College of Medicine
16 College Road
Singapore, 169854
Singapore

Wycliffe E. Wei

National Public Health and Epidemiology Unit, National Centre for Infectious Diseases ( email )

Yee-Sin Leo

National Centre for Infectious Diseases - Infectious Disease Research and Training Office

Singapore

Benjamin Ong

Ministry of Health, Singapore ( email )

College of Medicine
16 College Road
Singapore, 169854
Singapore

David Chien Lye

National Centre for Infectious Diseases

Singapore

Vernon J. Lee

Ministry of Health, Singapore ( email )

College of Medicine
16 College Road
Singapore, 169854
Singapore

Kelvin Bryan Tan

Ministry of Health, Singapore ( email )

College of Medicine
16 College Road
Singapore, 169854
Singapore

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