Vaccine Effectiveness Against COVID-19 Infection Among 12 to 18 year olds in Singapore
8 Pages Posted: 8 Jan 2022
Date Written: December 30, 2021
We studied the incidence of confirmed COVID-19 infection and symptomatic infection among adolescents aged 12 to 18 years old vaccinated with Pfizer-BioNTech/Comirnaty in Singapore. Full vaccination with 2 doses achieved vaccine effectiveness of 59% (95% CI 55% – 63%) against confirmed infection and 62% (95% CI 57% – 66%) against symptomatic infection, compared with unvaccinated adolescents. Among those fully vaccinated, gradual waning of immunity was observed over 4 months from completion of the second dose.
Funding: Funding: This study was not funded.
Declaration of Interests: The authors declare that they have no conflict of interest.
Ethics Approval Statement: This study was conducted as part of national COVID-19 public health response under the Infectious Disease Act, Ministry of Health, Singapore, with exemption from ethics review, as provided for under the Human Biomedical Research Act 2015, Singapore.
Keywords: COVID-19, SARS-CoV-2, vaccines, mRNA vaccine, adolescent
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