Vaccine Effectiveness Against COVID-19 Infection Among 12 to 18 year olds in Singapore

8 Pages Posted: 8 Jan 2022

See all articles by Calvin J. Chiew

Calvin J. Chiew

National Centre for Infectious Diseases, Singapore; Ministry of Health, Singapore

Premikha M

Ministry of Health, Singapore

Wycliffe E. Wei

National Public Health and Epidemiology Unit, National Centre for Infectious Diseases

Benjamin Ong

Ministry of Health, Singapore

David Chien Lye

National Centre for Infectious Diseases

Vernon J. Lee

Ministry of Health, Singapore

Kelvin Bryan Tan

Ministry of Health, Singapore

Date Written: December 30, 2021

Abstract

We studied the incidence of confirmed COVID-19 infection and symptomatic infection among adolescents aged 12 to 18 years old vaccinated with Pfizer-BioNTech/Comirnaty in Singapore. Full vaccination with 2 doses achieved vaccine effectiveness of 59% (95% CI 55% – 63%) against confirmed infection and 62% (95% CI 57% – 66%) against symptomatic infection, compared with unvaccinated adolescents. Among those fully vaccinated, gradual waning of immunity was observed over 4 months from completion of the second dose.

Note:
Funding: Funding: This study was not funded.

Declaration of Interests: The authors declare that they have no conflict of interest.

Ethics Approval Statement: This study was conducted as part of national COVID-19 public health response under the Infectious Disease Act, Ministry of Health, Singapore, with exemption from ethics review, as provided for under the Human Biomedical Research Act 2015, Singapore.

Keywords: COVID-19, SARS-CoV-2, vaccines, mRNA vaccine, adolescent

Suggested Citation

Chiew, Calvin J. and M, Premikha and Wei, Wycliffe E. and Ong, Benjamin and Lye, David Chien and Lee, Vernon J. and Tan, Kelvin Bryan, Vaccine Effectiveness Against COVID-19 Infection Among 12 to 18 year olds in Singapore (December 30, 2021). Available at SSRN: https://ssrn.com/abstract=3996796 or http://dx.doi.org/10.2139/ssrn.3996796

Calvin J. Chiew

National Centre for Infectious Diseases, Singapore

Singapore

Ministry of Health, Singapore ( email )

College of Medicine
16 College Road
Singapore, 169854
Singapore

Premikha M (Contact Author)

Ministry of Health, Singapore ( email )

College of Medicine
16 College Road
Singapore, 169854
Singapore

Wycliffe E. Wei

National Public Health and Epidemiology Unit, National Centre for Infectious Diseases ( email )

Benjamin Ong

Ministry of Health, Singapore ( email )

College of Medicine
16 College Road
Singapore, 169854
Singapore

David Chien Lye

National Centre for Infectious Diseases

Singapore

Vernon J. Lee

Ministry of Health, Singapore ( email )

College of Medicine
16 College Road
Singapore, 169854
Singapore

Kelvin Bryan Tan

Ministry of Health, Singapore ( email )

College of Medicine
16 College Road
Singapore, 169854
Singapore

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