Oxygen-Carrying Biomimetic Nanoplatform for Sonodynamic Killing of Bacteria and Treatment of Infection Diseases

Abstract

In this study, a new nanosonosensitizer (HFH@ZIF-8) that loads sonosensitizer hematoporphyrin monomethyl ether (HMME) into zeolitic imidazolate framework-8 (ZIF-8) for SDT, was constructed for killing multidrug-resistant (MDR) bacteria and treatment of in vivo infection diseases. In particular, the developed HFH@ZIF-8 exhibited unbeatable water-solubility, excellent biocompatibility, and extraordinary disease-targeting capability for delivering HMME and ablating the infected lesion. More importantly, the presence of oxygen-carrying hemoglobin for HFH@ZIF-8 can offer sufficient oxygen consumption by sonodynamic therapy (SDT), augmenting the efficacy of SDT by improving ROS generating efficiency against deep tissue multidrug-resistant bacterial infection. Therefore, this study paves a new avenue for treating infection disease, particularly for antibiotic resistant bacterial infection.

Keywords: sonodynamic therapy, metal organic frameworks (MOFs), infection diseases, nanomedicine, hemoglobin, multidrug-resistant (MDR) bacteria