Persistent SARS-CoV-2 Infection with Accumulation of Mutations in a Patient with Poorly Controlled HIV Infection
12 Pages Posted: 28 Jan 2022
Date Written: January 21, 2022
A 22-year-old female with uncontrolled advanced HIV infection was persistently infected with SARS-CoV-2 beta variant for 9 months, the virus accumulating >20 additional mutations. Antiretroviral therapy suppressed HIV and cleared SARS-CoV-2 within 6-9 weeks. Increased vigilance is warranted to benefit affected individuals and prevent the emergence of novel SARS-CoV-2 variants.
Funding: This work was supported by the Strategic Health Innovation Partnerships Unit of the South African Medical Research Council, with funds received from the South African Department of Science and Innovation, the Poliomyelitis Research Foundation, and the National Health Laboratory Service Research Trust.
Declaration of Interests: All authors have no conflicts of interest to declare.
Patient Informed Consent Statement: This case report was approved by the Health Research Ethics Committee of Stellenbosch University and the patient provided informed consent
Keywords: SARS-CoV-2, uncontrolled HIV infection, immunocompromised, infectious virus, mutations, COVID-19, antiretroviral therapy, persistent infection
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