Persistent SARS-CoV-2 Infection with Accumulation of Mutations in a Patient with Poorly Controlled HIV Infection

12 Pages Posted: 28 Jan 2022

See all articles by Tongai G. Maponga

Tongai G. Maponga

Stellenbosch University

Montenique Jeffries

Tygerberg Academic Hospital

Houriiyah Tegally

KwaZulu-Natal Research Innovation and Sequencing Platform - KRISP

Andrew D. Sutherland

Stellenbosch University - Faculty of Medicine and Health Sciences

Eduan Wilkinson

KwaZulu-Natal Research Innovation and Sequencing Platform - KRISP

Richard Lessells

University of KwaZulu-Natal - School of Laboratory Medicine and Medical Sciences

Nokukhanya Msomi

4Discipline of Virology, School of Laboratory Medicine and Medical Sciences and National Health Laboratory Service (NHLS), University of KwaZulu–Natal

Gert van Zyl

Stellenbosch University, Division of Medical Virology ; National Health Laboratory Service (NHLS), South Africa

Tulio de Oliveira

University of KwaZulu-Natal - School of Laboratory Medicine and Medical Sciences

Wolfgang Preiser

Division of Medical Virology

Date Written: January 21, 2022

Abstract

A 22-year-old female with uncontrolled advanced HIV infection was persistently infected with SARS-CoV-2 beta variant for 9 months, the virus accumulating >20 additional mutations. Antiretroviral therapy suppressed HIV and cleared SARS-CoV-2 within 6-9 weeks. Increased vigilance is warranted to benefit affected individuals and prevent the emergence of novel SARS-CoV-2 variants.

Note:
Funding: This work was supported by the Strategic Health Innovation Partnerships Unit of the South African Medical Research Council, with funds received from the South African Department of Science and Innovation, the Poliomyelitis Research Foundation, and the National Health Laboratory Service Research Trust.

Declaration of Interests: All authors have no conflicts of interest to declare.

Patient Informed Consent Statement: This case report was approved by the Health Research Ethics Committee of Stellenbosch University and the patient provided informed consent

Keywords: SARS-CoV-2, uncontrolled HIV infection, immunocompromised, infectious virus, mutations, COVID-19, antiretroviral therapy, persistent infection

Suggested Citation

Maponga, Tongai G. and Jeffries, Montenique and Tegally, Houriiyah and Sutherland, Andrew D. and Wilkinson, Eduan and Lessells, Richard and Msomi, Nokukhanya and van Zyl, Gert and de Oliveira, Tulio and Preiser, Wolfgang, Persistent SARS-CoV-2 Infection with Accumulation of Mutations in a Patient with Poorly Controlled HIV Infection (January 21, 2022). Available at SSRN: https://ssrn.com/abstract=4014499 or http://dx.doi.org/10.2139/ssrn.4014499

Tongai G. Maponga

Stellenbosch University

Stellenbosch, Western Cape
South Africa

Montenique Jeffries

Tygerberg Academic Hospital ( email )

Cape Town, 7505
South Africa

Houriiyah Tegally

KwaZulu-Natal Research Innovation and Sequencing Platform - KRISP ( email )

South Africa

Andrew D. Sutherland

Stellenbosch University - Faculty of Medicine and Health Sciences ( email )

Tygerberg
South Africa

Eduan Wilkinson

KwaZulu-Natal Research Innovation and Sequencing Platform - KRISP ( email )

South Africa

Richard Lessells

University of KwaZulu-Natal - School of Laboratory Medicine and Medical Sciences ( email )

Umbilo Road
Durban 4000, KZN 4000
South Africa

Nokukhanya Msomi

4Discipline of Virology, School of Laboratory Medicine and Medical Sciences and National Health Laboratory Service (NHLS), University of KwaZulu–Natal ( email )

Durban
South Africa

Gert Van Zyl

Stellenbosch University, Division of Medical Virology ( email )

Tygerberg
South Africa

National Health Laboratory Service (NHLS), South Africa ( email )

Modderfontein Road
Sandringham, Johannesburg
South Africa

Tulio De Oliveira

University of KwaZulu-Natal - School of Laboratory Medicine and Medical Sciences ( email )

Umbilo Road
Durban 4000, KZN 4000
South Africa

Wolfgang Preiser (Contact Author)

Division of Medical Virology ( email )

Tygerberg
South Africa
+27219389353 (Phone)

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