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Effect of Inactivated SARS-CoV-2 Vaccine on Thyroid Function and Autoimmunity

26 Pages Posted: 7 Feb 2022

See all articles by Liubing Li

Liubing Li

affiliation not provided to SSRN

Xinwen Chen

affiliation not provided to SSRN

Bin Li

Sun Yat-Sen University (SYSU), First Affiliated Hospital, Clinical Trial Unit

Dayue Liu

affiliation not provided to SSRN

Yihao Liu

Sun Yat-Sen University (SYSU), First Affiliated Hospital, Clinical Trial Unit

Ruohui Mo

affiliation not provided to SSRN

Fenghua Lai

affiliation not provided to SSRN

Rengyun Liu

affiliation not provided to SSRN

Sui Peng

Sun Yat-Sen University (SYSU), First Affiliated Hospital, Clinical Trial Unit; Sun Yat-sen University (SYSU) - Department of Gastroenterology and Hepatology

Yanbing Li

Sun Yat-sen University (SYSU) - Department of Endocrinology

Min Liu

affiliation not provided to SSRN

Haipeng Xiao

Sun Yat-sen University (SYSU) - Institute of Precision Medicine; Sun Yat-sen University (SYSU) - Department of Endocrinology

More...

Abstract

Background: There is limited knowledge regarding the potential impact of SARS-CoV-2 vaccines on the thyroid.

Methods: We performed a randomized controlled trial between April 15 and April 28, 2021, and a prospective cohort study between May 8 and June 30, 2021, enrolling recipients of the inactivated SARS-CoV-2 vaccine. Thyroid function, antithyroid antibody levels, and SARS-CoV-2 neutralizing antibody (NAb) levels were detected for each participant before receiving the first dose and 28 days after receiving the second dose.

Findings: A total of 657 recipients participated in the study. Among the 564 participants with normal thyroid function at baseline, 36 (6·38%) developed thyroid dysfunction. Of the 545 recipients with negative antithyroid antibodies at baseline, none developed abnormal antibodies after vaccination. Notably, 70 (75·27%) of the 93 recipients with thyroid dysfunction, returned to normal function after vaccination. The levels of anti-thyroid peroxidase antibody (TPOAb; 96·20%) and anti-thyroglobulin antibody (TgAb; 88·31%) remained positive after vaccination in most patients with abnormal values at baseline. However, the TgAb levels in more than half of the patients decreased. All of abnormal thyroid-stimulating hormone (TSH) receptor antibody (TRAb) levels at baseline decreased post-vaccination. Only the levels of total triiodothyronine (TT3), total thyroxine (TT4), TgAb pre-vaccination, and TT4 levels post-vaccination, showed a mild correlation with SARS-CoV-2 NAb titers.

Interpretation: Vaccination with an inactivated SARS-CoV-2 vaccine had no severe impact on thyroid function or antithyroid antibodies. Our study provides evidence-based support for the clinical application of SARS-CoV-2 inactivated vaccines in patients with thyroid diseases.Funding The Talent Program of the First Affiliated Hospital, Sun Yat-sen University.

Trial Registration Details: Both the randomized controlled trial and prospective cohort study were registered in the Chinese Clinical Trial Registry (ChiCTR2100045109 and ChiCTR2100042222, respectively).

Funding Information: The Talent Program of the First Affiliated Hospital, Sun Yat-sen University.

Declaration of Interests: The authors have no conflicts of interest to disclose.

Ethics Approval Statement: Both the randomized controlled trial and prospective cohort study were approved by the Ethic Committee of the First Affiliated Hospital of Sun Yat-sen University. Written informed consent was obtained from all participants.

Keywords: SARS-CoV-2, COVID-19, inactivated vaccine, thyroid function, antithyroid antibodies, neutralizing antibodies

Suggested Citation

Li, Liubing and Chen, Xinwen and Li, Bin and Liu, Dayue and Liu, Yihao and Mo, Ruohui and Lai, Fenghua and Liu, Rengyun and Peng, Sui and Li, Yanbing and Liu, Min and Xiao, Haipeng and Xiao, Haipeng, Effect of Inactivated SARS-CoV-2 Vaccine on Thyroid Function and Autoimmunity. Available at SSRN: https://ssrn.com/abstract=4028552 or http://dx.doi.org/10.2139/ssrn.4028552

Liubing Li

affiliation not provided to SSRN ( email )

No Address Available

Xinwen Chen

affiliation not provided to SSRN ( email )

No Address Available

Bin Li

Sun Yat-Sen University (SYSU), First Affiliated Hospital, Clinical Trial Unit ( email )

Dayue Liu

affiliation not provided to SSRN ( email )

No Address Available

Yihao Liu

Sun Yat-Sen University (SYSU), First Affiliated Hospital, Clinical Trial Unit ( email )

China

Ruohui Mo

affiliation not provided to SSRN ( email )

No Address Available

Fenghua Lai

affiliation not provided to SSRN ( email )

No Address Available

Rengyun Liu

affiliation not provided to SSRN ( email )

No Address Available

Sui Peng

Sun Yat-Sen University (SYSU), First Affiliated Hospital, Clinical Trial Unit ( email )

China

Sun Yat-sen University (SYSU) - Department of Gastroenterology and Hepatology

135, Xingang Xi Road
Guangdong, Guangdong 510275
China

Yanbing Li

Sun Yat-sen University (SYSU) - Department of Endocrinology ( email )

Guangzhou
China

Min Liu

affiliation not provided to SSRN ( email )

No Address Available

Haipeng Xiao (Contact Author)

Sun Yat-sen University (SYSU) - Institute of Precision Medicine ( email )

Guangzhou, Guangdong
China

Sun Yat-sen University (SYSU) - Department of Endocrinology ( email )

Guangzhou
China

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