Preprints with The Lancet is part of SSRN´s First Look, a place where journals identify content of interest prior to publication. Authors have opted in at submission to The Lancet family of journals to post their preprints on Preprints with The Lancet. The usual SSRN checks and a Lancet-specific check for appropriateness and transparency have been applied. Preprints available here are not Lancet publications or necessarily under review with a Lancet journal. These preprints are early stage research papers that have not been peer-reviewed. The findings should not be used for clinical or public health decision making and should not be presented to a lay audience without highlighting that they are preliminary and have not been peer-reviewed. For more information on this collaboration, see the comments published in The Lancet about the trial period, and our decision to make this a permanent offering, or visit The Lancet´s FAQ page, and for any feedback please contact firstname.lastname@example.org.
Non-Myotic Improvement in Near Vision: Special Topical Formulation for Presbyopia
16 Pages Posted: 21 Feb 2022More...
Purpose: To examine the possible relationship between miosis and improvement in near vision for reading after special topical formulation (FOV drops). This study was developed in a private practice center (Vejarano Foundation, Popayan, Colombia).
Methods: This was a prospective interventional study of consecutive presbiopic subjects who were tested for vision and pupil diameter before and after two hours of instillation of a special pilocarpine drop formulation for presbyopia. The drop contains both pilocarpine and phenylephrine. Included subjects were all consecutive presbiopic patients with distance refractive error between -1.75 and +2.00 D aged 40 to 70 years who accepted trying drops for reading purposes instead of glasses. Pre- and Post- drop instillation patients underwent subjective refraction, photopic and scotopic pupil diameter, and distance and near, monocular and binocular distance and near unaided logmar visual acuity testing. These main outcome measurements were correlated and studied with Student t tests.
Results: The study includes 446 subjects with mean age 50.5 +/- 5.8 years (227 were females, 50.9%). The mean spherical equivalent was +0.099+/-0.495 diopters and did not change significantly after the FOV drop. The scotopic pupil diameter decreased after the drop by 0.94+/-0.98mm. The near logmar visual acuity improved two lines after the drop. There were no significant differences in near visual acuity gain between those with smaller or bigger pupils (p=0.18).
Conclusions: The improvement in near vision with pilocarpine + phenylephrine FOV drops is independent of pupil change.
Funding Information: This study was supported by the Redi Tematica de Investigacion Cooperativa en Salud (RETICS), reference number RD16/0008/0012, funded by the Instituto de Salud Carlos III and co-funded by the European Regional Development Fund (ERDF), ‘‘A way to make Europe’’. No funding or sponsorship was received for the publication of this article.
Declaration of Interests: RI & JA declare no conflicts of interest. FV owns the patent for the FOV tears.
Ethics Approval Statement: The protocol adhered to the tenets of the Declaration of Helsinki and was approved by the Ethics Committee of Vejarano Ophthalmological Foundation in Colombia. Subjects signed informed consent before enrolment in the study.
Keywords: presbyopia, diluted pilocarpine eye drops
Suggested Citation: Suggested Citation