Maternal Short-Term Exposure to No2 During Pregnancy and its Relationship with Doppler Markers of Placental Function

23 Pages Posted: 16 Mar 2022

See all articles by Marc Josep Cahuana Bartra

Marc Josep Cahuana Bartra

Hospital Sant Joan de Deu

Edurne Mazarico-Gallego

Hospital Sant Joan de Deu

Alex Cahuana-Bartra

Hospital Sant Joan de Deu

Rosalia Pascal

Hospital Sant Joan de Deu

Lucia Alonso-Garcia

affiliation not provided to SSRN

Jaume Targa-Ballesta

affiliation not provided to SSRN

Concha Muñoz-Lozano

Hospital Sant Joan de Deu

Payam Dadvand

Barcelona Institute for Global Health (ISGlobal)

Maria Dolores Gomez-Roig

Hospital Sant Joan de Deu

Abstract

BackgroundMaternal exposure to air pollution has been associated with poor obstetrics outcomes. However, the available evidence on the impact of maternal exposure to air pollution on placental function is still scarce and is based on estimated ambient levels of air pollutants.ObjectiveTo evaluate the association between short-term maternal exposure to NO 2 based on the objective measure of personal NO 2 exposure and Doppler markers of placental function.MethodsProspective cohort study including 101 singleton pregnancies recruited at Hospital Sant Joan de Déu, Barcelona (Spain) between January 2017 and April 2018. NO 2 diffusion tubes were worn by pregnant women to measure personal exposure to NO 2 between weeks 28 and 32 of their pregnancy. Placental function was evaluated at the 32 nd week of gestation by Doppler evaluation of mean uterine arteries (UtA) PI, umbilical artery (UA) pulsatility index (PI), middle cerebral artery (MCA) PI, cerebroplacental ratio (CPR), and ductus venosus (DV) PI. Linear regression models were applied to estimate the association of personal NO 2 exposure and Doppler markers of placental function (one at a time), controlled for relevant covariates.ResultsExposure to higher levels of personal exposure to NO 2 was significantly associated with lower mean uterine artery PI. We also observed some suggestions for an inverse association between this exposure and CPR. The findings for the rest of Doppler markers were not conclusive.ConclusionsOur results suggests that higher exposure to NO 2 between 28 th and 32 nd weeks of gestation could interfere with Doppler markers of placental function, potentially indicating a certain degree of cerebral vasodilatation with a decrease of mean uterine arteries PI.

Keywords: Air pollution, nitrogen oxides, gestation, personal monitoring, foetal growth, maternal-foetal Doppler

Suggested Citation

Cahuana Bartra, Marc Josep and Mazarico-Gallego, Edurne and Cahuana-Bartra, Alex and Pascal, Rosalia and Alonso-Garcia, Lucia and Targa-Ballesta, Jaume and Muñoz-Lozano, Concha and Dadvand, Payam and Gomez-Roig, Maria Dolores, Maternal Short-Term Exposure to No2 During Pregnancy and its Relationship with Doppler Markers of Placental Function. Available at SSRN: https://ssrn.com/abstract=4050608 or http://dx.doi.org/10.2139/ssrn.4050608

Marc Josep Cahuana Bartra (Contact Author)

Hospital Sant Joan de Deu ( email )

Passeig Sant Joan de Deu 2
Barcelona, 08950
Spain

Edurne Mazarico-Gallego

Hospital Sant Joan de Deu ( email )

Passeig Sant Joan de Deu 2
Barcelona, 08950
Spain

Alex Cahuana-Bartra

Hospital Sant Joan de Deu ( email )

Passeig Sant Joan de Deu 2
Barcelona, 08950
Spain

Rosalia Pascal

Hospital Sant Joan de Deu ( email )

Lucia Alonso-Garcia

affiliation not provided to SSRN ( email )

No Address Available

Jaume Targa-Ballesta

affiliation not provided to SSRN ( email )

No Address Available

Concha Muñoz-Lozano

Hospital Sant Joan de Deu ( email )

Passeig Sant Joan de Deu 2
Barcelona, 08950
Spain

Payam Dadvand

Barcelona Institute for Global Health (ISGlobal) ( email )

Barcelona, 08003
Spain

Maria Dolores Gomez-Roig

Hospital Sant Joan de Deu ( email )

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