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Recent Infection With HCoV-OC43 Is Associated With Protection Against Sars-Cov-2 Infection

32 Pages Posted: 23 Mar 2022 Publication Status: Published

See all articles by A.H. Ayesha Lavell

A.H. Ayesha Lavell

VU University Amsterdam - Department of Internal Medicine

Jonne J. Sikkens

VU University Amsterdam - Department of Internal Medicine; University of Amsterdam - Amsterdam Institute for Infection and Immunity

Arthur WD Edridge

University of Amsterdam - Department of Medical Microbiology and Infection Prevention

Karlijn van der Straten

University of Amsterdam - Department of Medical Microbiology and Infection Prevention

Melissa Oomen

University of Amsterdam - Department of Medical Microbiology and Infection Prevention

David TP Buis

VU University Amsterdam - Department of Internal Medicine

Michiel Schinkel

University of Amsterdam - Center for Experimental and Molecular Medicine

Judith A. Burger

University of Amsterdam - Amsterdam Institute for Infection and Immunity

Meliawati Poniman

University of Amsterdam - Department of Medical Microbiology and Infection Prevention

Menno D. de Jong

University of Amsterdam - Department of Medical Microbiology and Infection Prevention

Godelieve J. de Bree

University of Amsterdam - Department of Internal Medicine

Edgar JG Peters

VU University Amsterdam - Department of Internal Medicine

Yvo M. Smulders

VU University Amsterdam - Department of Internal Medicine

Rogier Sanders

University of Amsterdam - Department of Medical Microbiology; University of Amsterdam - Department of Medical Microbiology and Infection Prevention

Marit J. van Gils

University of Amsterdam - Department of Medical Microbiology and Infection Prevention

Lia van der Hoek

University of Amsterdam - Department of Medical Microbiology and Infection Prevention

Marije Bomers

VU University Amsterdam - Department of Internal Medicine; University of Amsterdam - Amsterdam Institute for Infection and Immunity

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Abstract

Antibodies against seasonal human coronaviruses (HCoVs) are known to cross-react with SARS-CoV-2, but data on cross-protective effects of prior HCoV infections are conflicting. In a prospective cohort of healthcare workers (HCW), we studied the association between seasonal HCoV (OC43, HKU1, 229E and NL63) nucleocapsid protein IgG and SARS-CoV-2 infection during the first pandemic wave in the Netherlands (March 2020- June 2020), by 4-weekly serum sampling. HCW with HCoV-OC43 antibody levels in the highest quartile, were less likely to become SARS-CoV-2 seropositive when compared to those with lower levels (6/32, 18.8%, vs 42/97, 43.4%, respectively: p=0.019; HR 0.37, 95% CI 0.16-0.88). We found no significant association with HCoV-OC43 spike protein IgG, or with antibodies against other HCoVs. Our results indicate that a recent infection with HCoV-OC43 has a protective effect against SARS-CoV-2 infection; this supports and informs efforts to develop pancoronavirus vaccines.

Funding Information: This work was supported by the Netherlands Organization for Scientific Research (NWO) ZonMw (S3 study, grant agreement no. 10430022010023 to M.K.B.) and the Corona Research Fund Amsterdam UMC.

Conflict of Interests: The authors declare no competing interests.

Ethical Approval: The study was approved by the medical ethics review committee of both hospitals, and written informed consent was obtained from each participant.

Keywords: Coronavirus, antibodies, OC43, NL63, HKU1, 229E, SARS-CoV-2, COVID-19

Suggested Citation

Lavell, A.H. Ayesha and Sikkens, Jonne J. and Edridge, Arthur WD and van der Straten, Karlijn and Oomen, Melissa and Buis, David TP and Schinkel, Michiel and Burger, Judith A. and Poniman, Meliawati and de Jong, Menno D. and de Bree, Godelieve J. and Peters, Edgar JG and Smulders, Yvo M. and Sanders, Rogier and van Gils, Marit J. and van der Hoek, Lia and Bomers, Marije, Recent Infection With HCoV-OC43 Is Associated With Protection Against Sars-Cov-2 Infection. Available at SSRN: https://ssrn.com/abstract=4065078 or http://dx.doi.org/10.2139/ssrn.4065078
This version of the paper has not been formally peer reviewed.

A.H. Ayesha Lavell

VU University Amsterdam - Department of Internal Medicine ( email )

Amsterdam
Netherlands

Jonne J. Sikkens

VU University Amsterdam - Department of Internal Medicine ( email )

Amsterdam
Netherlands

University of Amsterdam - Amsterdam Institute for Infection and Immunity ( email )

De Boelelaan 1117
Amsterdam, 1081 HV
Netherlands

Arthur WD Edridge

University of Amsterdam - Department of Medical Microbiology and Infection Prevention ( email )

Amsterdam
Netherlands

Karlijn Van der Straten

University of Amsterdam - Department of Medical Microbiology and Infection Prevention ( email )

Amsterdam
Netherlands

Melissa Oomen

University of Amsterdam - Department of Medical Microbiology and Infection Prevention ( email )

Amsterdam
Netherlands

David TP Buis

VU University Amsterdam - Department of Internal Medicine ( email )

Amsterdam
Netherlands

Michiel Schinkel

University of Amsterdam - Center for Experimental and Molecular Medicine ( email )

Amsterdam
Netherlands

Judith A. Burger

University of Amsterdam - Amsterdam Institute for Infection and Immunity ( email )

Meliawati Poniman

University of Amsterdam - Department of Medical Microbiology and Infection Prevention ( email )

Amsterdam
Netherlands

Menno D. De Jong

University of Amsterdam - Department of Medical Microbiology and Infection Prevention ( email )

Amsterdam
Netherlands

Godelieve J. De Bree

University of Amsterdam - Department of Internal Medicine ( email )

Amsterdam, 1105 AZ
Netherlands

Edgar JG Peters

VU University Amsterdam - Department of Internal Medicine ( email )

Amsterdam
Netherlands

Yvo M. Smulders

VU University Amsterdam - Department of Internal Medicine ( email )

Amsterdam
Netherlands

Rogier Sanders

University of Amsterdam - Department of Medical Microbiology ( email )

University of Amsterdam - Department of Medical Microbiology and Infection Prevention ( email )

Amsterdam
Netherlands

Marit J. Van Gils

University of Amsterdam - Department of Medical Microbiology and Infection Prevention ( email )

Amsterdam
Netherlands

Lia Van der Hoek

University of Amsterdam - Department of Medical Microbiology and Infection Prevention ( email )

Amsterdam
Netherlands

Marije Bomers (Contact Author)

VU University Amsterdam - Department of Internal Medicine ( email )

Amsterdam
Netherlands

University of Amsterdam - Amsterdam Institute for Infection and Immunity

De Boelelaan 1117
Amsterdam, 1081 HV
Netherlands

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