Toward Wearable Biosensor with Ag Coated Quartz Fabric as Flexible Surface-Enhanced Raman Scattering Substrate
20 Pages Posted: 29 Mar 2022
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Toward Wearable Biosensor with Ag Coated Quartz Fabric as Flexible Surface-Enhanced Raman Scattering Substrate
Toward Wearable Biosensor with Ag Coated Quartz Fabric as Flexible Surface-Enhanced Raman Scattering Substrate
Abstract
The urea concentration in human sweat is directly related to kidney health, so highly accurate and rapid quantitative detection is essential for patients who suffer from kidney disease as part of the daily monitoring of their urea concentration. Therefore, a flexible surface-enhanced Raman scattered (FSERS) substrate has been developed and used as biosensor for rapid and accurate quantification of urea in human sweat in this study. Silver nanoparticles coated onto quartz fabric is used as the FSERS substrate and its wearability after machine-washing, crocking and a duration of storage time is investigated, as well as its SERS sensing performance. The results indicate that the prepared FSERS substrate shows an excellent enhancement performance with an enhancement factor of 3.4×10 5 , limit of detection below 10 -8 M/L, good signal reproducibility with an RSD of 5.31%, good signal stability with an RSD of 3.54%, as well as excellent wearability. By integrating the FSERS substrate into a garment collar and attaching the substrate onto a glove, and checking the signals with a portable Raman spectrometer, the prepared FSERS substrate shows excellent detection performance of urea concentrations with high accuracy. The novel FSERS substrate, as a wearable biosensor, has excellent potential for monitoring daily health conditions.
Keywords: FSERS, wearable biosensor, detection of urea, healthcare
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