A Cerium-Based Metal-Organic Framework as Adsorbent for the 99mo/99mtc Generator

Abstract

The cerium-based metal-organic framework UiO-66 (Ce) was examined as a potential adsorbent for the 99Mo/99mTc generator. The results show that the adsorbent had an outstanding adsorption performance, reaching up to 475 mg/g adsorption capacity at pH 3. The adsorption mechanism was proposed, where the adsorption was governed by hydrogen bonds, Ce-O-Mo coordination, π-anions and electrostatic interaction. Additionally, the adsorbent exhibited excellent radiation stability and good adsorption performance when radioactive 99Mo was applied. A 99Mo/99mTc generator was fabricated with UiO-66 (Ce) as adsorbent and its performance was evaluated over two weeks. The elution results showed that 92±3% of 99mTc elution efficiency can be obtained with acceptable cerium breakthrough, which revealed a promising application aspect for UiO-66 (Ce) as adsorbents to prepare the 99Mo/99mTc generator.

Keywords: UiO-66 (Ce), Molybdenum, Adsorption mechanism, 99Mo/99mTc generator