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Effect of Sarcopenia on Mortality in Type 2 Diabetes: A Long-Term Follow-Up Propensity Score–Matched Diabetes Cohort Study

34 Pages Posted: 11 Apr 2022

See all articles by Wan-Ming Chen

Wan-Ming Chen

Fu Jen Catholic University - Graduate Institute of Business Administration

Mingchih Chen

Fu Jen Catholic University - Graduate Institute of Business Administration

Ben-Chang Shia

Fu Jen Catholic University - Graduate Institute of Business Administration

Szu-Yuan Wu

Fu Jen Catholic University - Graduate Institute of Business Administration; Asia University - Department of Food Nutrition and Health Biotechnology; Lotung Poh-Ai Hospital - Division of Radiation Oncology; Lotung Poh-Ai Hospital - Big Data Center; Asia University - Department of Healthcare Administration; Taipei Medical University - Department of Radiation Oncology

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Abstract

Purpose: The effect of sarcopenia on the survival of patients with type 2 diabetes remains unclear. Therefore, we designed a propensity score–matched population-based cohort study to compare the patients with diabetes with or without sarcopenia.

Patients and Methods: We included patients with type 2 diabetes and categorized them into two groups according to whether they had sarcopenia and compared their survival; patients in the groups were matched at a ratio of 1:2.

Results: The matching process yielded a final cohort of 201,698 patients (132,805 and 68,893 in the sarcopenia and nonsarcopenia diabetes groups, respectively) who were eligible for further analysis. According to both univariate and multivariate Cox regression analyses, the adjusted hazard ratios (aHRs; 95% confidence interval [CI]) of all-cause death for the sarcopenia diabetes group compared with the control group: 1.35 (1.33–1.38; P < 0.001). The aHRs (95% CIs) of all-cause death for those aged 41–50, 51–60, and >60 years (compared with those aged ≤40 years) were 1.53 (1.48–1.60), 2.61 (2.52–2.72), and 6.21 (5.99–6.45), respectively. The aHR (95% CI) of all-cause death for the male patients compared with the female patients was 1.56 (1.54–1.60). The aHRs (95% CIs) of all-cause death for those with adapted Diabetes Complications Severity Index (aDCSI) scores of 1, 2, 3, 4, and ≥5 (compared with an aDCSI score of 0) were 1.01 (1.00–1.14), 1.38 (1.35–1.42), 1.58 (1.54–1.63), and 2.23 (2.14–2.33), respectively.

Conclusion: Patients with type 2 diabetes and sarcopenia had higher mortality than did those without sarcopenia.

Funding: Lo-Hsu Medical Foundation, LotungPoh-Ai Hospital, supports Szu-Yuan Wu’s work (Funding Number: 10908, 10909, 11001, 11002, 11003, 11006

Declaration of Interest: None to declare.

Ethical Approval: The study protocols were reviewed and approved by the Institutional Review Board of Tzu-Chi Medical Foundation (IRB109-015-B).

Keywords: type 2 diabetes, sarcopenia, nonsarcopenia, survival, prognostic factors

Suggested Citation

Chen, Wan-Ming and Chen, Mingchih and Shia, Ben-Chang and Wu, Szu-Yuan, Effect of Sarcopenia on Mortality in Type 2 Diabetes: A Long-Term Follow-Up Propensity Score–Matched Diabetes Cohort Study. Available at SSRN: https://ssrn.com/abstract=4081083 or http://dx.doi.org/10.2139/ssrn.4081083

Wan-Ming Chen

Fu Jen Catholic University - Graduate Institute of Business Administration ( email )

Mingchih Chen

Fu Jen Catholic University - Graduate Institute of Business Administration ( email )

Ben-Chang Shia

Fu Jen Catholic University - Graduate Institute of Business Administration ( email )

Szu-Yuan Wu (Contact Author)

Fu Jen Catholic University - Graduate Institute of Business Administration ( email )

Asia University - Department of Food Nutrition and Health Biotechnology ( email )

Taiwan

Lotung Poh-Ai Hospital - Division of Radiation Oncology ( email )

Taiwan

Lotung Poh-Ai Hospital - Big Data Center ( email )

Taiwan

Asia University - Department of Healthcare Administration ( email )

Taiwan

Taipei Medical University - Department of Radiation Oncology ( email )

No. 111, Section 3
Hsing-Long Road
Taipei, 116
Taiwan

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