Disease Burden in Individuals with Symptomatic Undiagnosed Asthma or COPD

22 Pages Posted: 23 Apr 2022

See all articles by Fatmah Fahad Alhabeeb

Fatmah Fahad Alhabeeb

University of Ottawa

G. A. Whitmore

McGill University

kathy vandemheen

University of Ottawa

mark fitzgerald

Vancouver Coastal Health Research Institute

celine bergeron

Vancouver Coastal Health Research Institute

catherine lemiere

affiliation not provided to SSRN

Louis Philippe Boulet

Université Laval - Quebec Heart and Lung Institute

Stephen field

University of Calgary

erika penz

University of Saskatchewan

Andrew McIvor

McMaster University

samir gupta

affiliation not provided to SSRN

irvin mayers

University of Alberta

mohit bhutani

University of Alberta

paul hernandez

Dalhousie University

diane lougheed

affiliation not provided to SSRN

Christopher Licskai

Western University - Schulich School of Medicine and Dentistry

tanweer azher

affiliation not provided to SSRN

Andréanne Côté

Université Laval

martha ainslie

University of Manitoba

ian fraser

Michael Garron Hospital Foundation

masoud mahdavian

affiliation not provided to SSRN

Shawn D. Aaron

University of Ottawa; The Ottawa Hospital

Abstract

Background: The actual burden of COPD and asthma may be much higher than appreciated, since a large proportion of individuals are not diagnosed.

Methods: This cross-sectional case-finding study used data from the Undiagnosed COPD and Asthma Population (UCAP) study. Adult subjects with respiratory symptoms who had no history of diagnosed lung disease were recruited in a two-step case-finding process using random digit-dialling of land lines and cell phones located within a 90-minute radius of 16 Canadian study sites. Participants were assessed for COPD, asthma or no airflow obstruction using pre- and post-bronchodilator spirometry based on American Thoracic Society diagnostic criteria. Our study objective was to compare health care utilization, burden of symptoms and quality of life in subjects with self-reported respiratory symptoms who were subsequently found to have undiagnosed airflow obstruction compared to those having no airflow obstruction.

Results: 1660 participants were recruited, of these 1615 had adequate spirometry and 331 (20.5%) subjects met spirometry criteria for asthma or COPD. Subjects with undiagnosed asthma or COPD had increased respiratory symptoms as assessed by the COPD Assessment Test (CAT), and higher St. George’s Respiratory Questionnaire (SGRQ) scores indicating worse health related quality of life, compared to subjects with no airflow obstruction. No between-group differences were found in health care utilization or work or school absenteeism.

Conclusion: Undiagnosed asthma and COPD are common in Canadian adults experiencing breathing problems and are associated with a greater burden of symptoms and poorer health-related quality of life.

Note:
Funding Information: Canadian Institutes of Health Research- FDN grant #154322.

Declaration of Interests: All authors in this paper declare that they have no conflict of interest.

Ethics Approval Statement: The study was approved by The Ottawa Health Science Network Research Ethics Board as well as the Ethics Boards of the other 15 participating study sites in Ontario. All enrolled subjects signed informed, written consent.

Keywords: Asthma, COPD, case-finding, undiagnosed, questionnaire, obstructive lung disease

Suggested Citation

Alhabeeb, Fatmah Fahad and Whitmore, G. A. and vandemheen, kathy and fitzgerald, mark and bergeron, celine and lemiere, catherine and Boulet, Louis Philippe and field, Stephen and penz, erika and McIvor, Andrew and gupta, samir and mayers, irvin and bhutani, mohit and hernandez, paul and lougheed, diane and Licskai, Christopher and azher, tanweer and Côté, Andréanne and ainslie, martha and fraser, ian and mahdavian, masoud and Aaron, Shawn D., Disease Burden in Individuals with Symptomatic Undiagnosed Asthma or COPD. Available at SSRN: https://ssrn.com/abstract=4091329 or http://dx.doi.org/10.2139/ssrn.4091329

Fatmah Fahad Alhabeeb (Contact Author)

University of Ottawa ( email )

2292 Edwin Crescent
Ottawa, K2C 1H7
Canada

G. A. Whitmore

McGill University ( email )

1001 Sherbrooke St. West
Montreal, Quebec H3A 1G5
Canada
514-398-4049 (Phone)
514-398-3876 (Fax)

Kathy Vandemheen

University of Ottawa ( email )

2292 Edwin Crescent
Ottawa, K2C 1H7
Canada

Mark Fitzgerald

Vancouver Coastal Health Research Institute ( email )

Room 3665
910 West 10th Avenue
Vancouver, V5Z 1M9
Canada

Celine Bergeron

Vancouver Coastal Health Research Institute ( email )

Room 3665
910 West 10th Avenue
Vancouver, V5Z 1M9
Canada

Catherine Lemiere

affiliation not provided to SSRN ( email )

No Address Available

Louis Philippe Boulet

Université Laval - Quebec Heart and Lung Institute ( email )

Stephen Field

University of Calgary ( email )

University Drive
Calgary, T2N 1N4
Canada

Erika Penz

University of Saskatchewan ( email )

College of Education
Saskatoon, S7N 5A7
Canada

Andrew McIvor

McMaster University ( email )

1280 Main Street West
Hamilton
Canada

Samir Gupta

affiliation not provided to SSRN ( email )

No Address Available

Irvin Mayers

University of Alberta ( email )

Edmonton, T6G 2R3
Canada

Mohit Bhutani

University of Alberta ( email )

Edmonton, T6G 2R3
Canada

Paul Hernandez

Dalhousie University ( email )

6225 University Avenue
Halifax, B3H 4H7
Canada

Diane Lougheed

affiliation not provided to SSRN ( email )

No Address Available

Christopher Licskai

Western University - Schulich School of Medicine and Dentistry ( email )

Tanweer Azher

affiliation not provided to SSRN ( email )

No Address Available

Andréanne Côté

Université Laval ( email )

2214 Pavillon J-A. DeSeve
Quebec, Quebec G1K 7P4
Canada

Martha Ainslie

University of Manitoba ( email )

501 F.A. Bldg
Winnipeg R3T 5V4, R3T 5V5
Canada

Ian Fraser

Michael Garron Hospital Foundation ( email )

Masoud Mahdavian

affiliation not provided to SSRN ( email )

No Address Available

Shawn D. Aaron

University of Ottawa ( email )

The Ottawa Hospital ( email )

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