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Lactate Supply Overtakes Glucose When Neural Computational and Cognitive Loads Scale Up

69 Pages Posted: 7 May 2022 Publication Status: Review Complete

See all articles by Yulia Dembitskaya

Yulia Dembitskaya

Université PSL - Dynamics and Pathophysiology of Neuronal Networks Team

Charlotte Piette

Université PSL - Dynamics and Pathophysiology of Neuronal Networks Team

Sylvie Perez

Université PSL - Dynamics and Pathophysiology of Neuronal Networks Team; Université Paris VI Pierre et Marie Curie - Center for Interdisciplinary Research in Biology (CIRB)

Hugues Berry

INRIA

Pierre J. Magistretti

King Abdullah University of Science and Technology - Biological and Environmental Science and Engineering Division

Laurent Venance

Université PSL - Dynamics and Pathophysiology of Neuronal Networks Team; Modelling and Analysis for Medical and Biological Applications (MAMBA)

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Abstract

SUMMARYThe neural computational power is determined by neuroenergetics, but how and which energy substrates are allocated to various forms of memory engram is unclear. To solve this question, we asked whether neuronal fueling by glucose or lactate scales differently upon increasing neural computation and cognitive loads. Here, using electrophysiology, two-photon imaging, cognitive tasks and mathematical modeling, we show that both glucose and lactate are involved in engram formation, with lactate supporting long-term synaptic plasticity evoked by high stimulation load activity patterns and high attentional load in cognitive tasks, and glucose being sufficient for less demanding neural computation and learning tasks. Overall, these results demonstrate that glucose and lactate metabolisms are differentially engaged in neuronal fueling depending on the complexity of the activity-dependent plasticity and behavior.

Keywords: neuroenergetics, glucose, lactate, synaptic plasticity, spike-timing-dependent plasticity, cognitive tasks, hippocampus

Suggested Citation

Dembitskaya, Yulia and Piette, Charlotte and Perez, Sylvie and Berry, Hugues and Magistretti, Pierre J. and Venance, Laurent, Lactate Supply Overtakes Glucose When Neural Computational and Cognitive Loads Scale Up. Available at SSRN: https://ssrn.com/abstract=4102619 or http://dx.doi.org/10.2139/ssrn.4102619
This version of the paper has not been formally peer reviewed.

Yulia Dembitskaya

Université PSL - Dynamics and Pathophysiology of Neuronal Networks Team ( email )

Charlotte Piette

Université PSL - Dynamics and Pathophysiology of Neuronal Networks Team ( email )

Sylvie Perez

Université PSL - Dynamics and Pathophysiology of Neuronal Networks Team ( email )

Université Paris VI Pierre et Marie Curie - Center for Interdisciplinary Research in Biology (CIRB) ( email )

11 Place Marcellin Berthelot
Paris, 75005
France

Hugues Berry

INRIA ( email )

Domaine de Voluceau
Rocquencourt
Chesnay, 78153
France

Pierre J. Magistretti

King Abdullah University of Science and Technology - Biological and Environmental Science and Engineering Division ( email )

Laurent Venance (Contact Author)

Université PSL - Dynamics and Pathophysiology of Neuronal Networks Team ( email )

Paris
France

Modelling and Analysis for Medical and Biological Applications (MAMBA) ( email )

Paris
France

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